Effect of topical insulin on cutaneous wound healing in rats with or without acute diabetes

S Apikoglu‐Rabus, FV Izzettin, P Turan… - Clinical and …, 2010 - academic.oup.com
Background. Diabetes is a condition known even in its early stages to impair the normal
course of wound healing, thus leading to chronic wounds. The role of insulin in the …

Effect of topical insulin on second-degree burns in diabetic rats

F Azevedo, A Pessoa, G Moreira… - … research for nursing, 2016 - journals.sagepub.com
The healing process is complex in diabetic wounds, and the healing mechanism of burn
wounds is different from that of incisional or excisional wounds. Data from our previous study …

Effects of topical insulin on wound healing: a review of animal and human evidences

J Wang, J Xu - Diabetes, Metabolic Syndrome and Obesity, 2020 - Taylor & Francis
Wound healing is a complex biological process that repairs damaged tissues and restores
skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a …

[HTML][HTML] Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial

MHM Lima, AM Caricilli, LL de Abreu, EP Araújo… - PloS one, 2012 - journals.plos.org
Background Wound healing is impaired in diabetes mellitus, but the mechanisms involved in
this process are virtually unknown. Proteins belonging to the insulin signaling pathway …

Effects of insulin on wound healing: a review of animal and human evidences

A Oryan, E Alemzadeh - Life sciences, 2017 - Elsevier
Aims Several studies have indicated that insulin that is used in reducing blood glucose is
also affective on wound healing by various mechanisms. To understand the outcomes of …

Influence of insulin therapy on burn wound healing in rats

SV Madibally, V Solomon, RN Mitchell… - Journal of surgical …, 2003 - Elsevier
Background. Insulin is proposed as a therapy for suppressing muscle wasting after burn
trauma although the long-term effects of this therapy on wound healing are not yet known …

Effects of insulin on wound healing in diabetic mice

EJ Weringer, JM Kelso, IY Tamai… - European Journal of …, 1982 - academic.oup.com
In the present study wound healing was examined in normal C57B1/6 male mice, diabetic
mice, non-treated; and in diabetic mice treated with insulin. Small dermal wounds were …

Effects of topical application of insulin on the wound healing in scalded rats

Y Liu, X Zhang, Z Zhang, PY Fang… - Zhonghua Shao Shang za …, 2004 - europepmc.org
Objective To investigate the effects of topical application of small dose of insulin on the
wound healing of the scalded rats, so as to explore its mechanism. Methods The rats …

Effect of systemic insulin treatment on diabetic wound healing

N Vatankhah, Y Jahangiri, GJ Landry… - Wound Repair and …, 2017 - Wiley Online Library
This study investigates if different diabetic treatment regimens affect diabetic foot ulcer
healing. From January 2013 to December 2014, 107 diabetic foot ulcers in 85 patients were …

Topical insulin application improves healing by regulating the wound inflammatory response

X Chen, Y Liu, X Zhang - Wound Repair and Regeneration, 2012 - Wiley Online Library
Inflammation, the initiating stage of wound healing, is characterized by increased
endothelial permeability, infiltration of inflammatory cells, and secretion of numerous growth …