Indole alkaloids, which are abundant in nature, are a significant source of pharmacologically
active compounds. Indole alkaloids have the potential to exert anticancer activity via various …

Autophagy is a critical cellular adaptive response in tumor formation. Nutritional deficiency
and hypoxia exacerbate autophagic flux in established malignancies, promoting tumor cell …

Objectives Autophagy, a highly conserved lysosomal degradation process in eukaryotic
cells, can digest long‐lived proteins and damaged organelles through vesicular trafficking …

Baicalein (BAI) is a natural flavonoid. It has been shown that BAI has anticancer effects, but
the molecular mechanism is still unclear. The aim of the current study was to confirm …

Diindolylmethane (DIM), a class of relatively non-toxic indole derivatives from cruciferous
vegetables, has been reported as a promising anticancer phytochemical, but the underlying …

PANC-1 human pancreatic cancer cells are characterized by their ability to proliferate
aggressively under hypovascular and hypoxic conditions in the tumor microenvironment …

Aims Isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, has previously been
reported to have anti-tumor effects in vivo and in vitro. However, the mechanisms whereby …

Autophagy inhibition has been widely accepted as a promising therapeutic strategy in
cancer, while the lack of effective and specific autophagy inhibitors hinders its application …

Autophagy is a highly conserved catabolic process and participates in a variety of cellular
biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B …

Indole, a heterocyclic organic compound, is one of the most promising heterocycles found in
natural and synthetic sources since its derivatives possess fascinating structural diversity …