Integrating autophagy and metabolism in cancer

H Cheong - Archives of pharmacal research, 2015 - Springer
Autophagy is a catabolic process mediated by lysosomal degradation and is a key player in
regulating cellular metabolism during cancer progression. Autophagy maintains cellular …

Autophagy regulators as potential cancer therapeutic agents: a review

S Li, L Wang, Y Hu, R Sheng - Current topics in medicinal …, 2015 - ingentaconnect.com
Autophagy is an important basic metabolic mechanism by engulfing and degrading the
unnecessary or dysfunctional cellular components within double-membered autolysosomes …

Natural compounds modulate the crosstalk between apoptosis-and autophagy-regulated signaling pathways: Controlling the uncontrolled expansion of tumor cells

C Braicu, O Zanoaga, AA Zimta, AB Tigu… - Seminars in Cancer …, 2022 - Elsevier
Due to the high number of annual cancer–related deaths, and the economic burden that this
malignancy affects today's society, the study of compounds isolated from natural sources …

Autophagy modulation as a target for anticancer drug discovery

X Li, H Xu, Y Liu, N An, S Zhao, J Bao - Acta Pharmacologica Sinica, 2013 - nature.com
Autophagy, an evolutionarily conserved catabolic process involving the engulfment and
degradation of non-essential or abnormal cellular organelles and proteins, is crucial for …

Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells

S Raha, S Yumnam, GE Hong… - International …, 2015 - spandidos-publications.com
Naringin, one of the major bioflavonoid of Citrus, has been demonstrated as potential
anticancer agent. However, the underlying anticancer mechanism still needs to be explored …

Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer

X Pang, X Zhang, Y Jiang, Q Su, Q Li, Z Li - Biomolecules, 2021 - mdpi.com
Autophagy, which is a conserved biological process and essential mechanism in
maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic …

Monoterpenes modulating autophagy: A review study

M Ashrafizadeh, Z Ahmadi… - Basic & Clinical …, 2020 - Wiley Online Library
From the beginning of the 21st century, much attention has been made towards the
medicinal herbs due to their low side effects and valuable biological activities. Among them …

A combination of indole-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and …

Y Nakamura, S Yogosawa, Y Izutani, H Watanabe… - Molecular cancer, 2009 - Springer
Background The chemopreventive effects of dietary phytochemicals on malignant tumors
have been studied extensively because of a relative lack of toxicity. To achieve desirable …

Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

J Liu, Y Wu, S Meng, P Xu, S Li, Y Li, X Hu, L Ouyang… - Molecular cancer, 2024 - Springer
Eukaryotic cells engage in autophagy, an internal process of self-degradation through
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …

Cell death triggered by the autophagy inhibitory drug 3-methyladenine in growing conditions proceeds with DNA damage

J Chicote, VJ Yuste, J Boix, J Ribas - Frontiers in Pharmacology, 2020 - frontiersin.org
Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with
pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified …