Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment

IWH Jarvis, K Dreij, Å Mattsson, B Jernström, U Stenius - Toxicology, 2014 - Elsevier
In this review we discuss the effects of exposure to complex PAH mixtures in vitro and in vivo
on mechanisms related to carcinogenesis. Of particular concern regarding exposure to …

Cancer Risk Assessment of Airborne PAHs Based on in Vitro Mixture Potency Factors

K Dreij, Å Mattsson, IWH Jarvis, H Lim… - … science & technology, 2017 - ACS Publications
Complex mixtures of polycyclic aromatic hydrocarbons (PAHs) are common environmental
pollutants associated with adverse human health effects including cancer. However, the risk …

Binary PAH mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation

YCM Staal, DGAJ Hebels, MH Van Herwijnen… - …, 2007 - academic.oup.com
Polycyclic aromatic hydrocarbons (PAHs) cover a wide range of structurally related
compounds which differ greatly in their carcinogenic potency. PAH exposure usually occurs …

The genotoxicity of priority polycyclic aromatic hydrocarbons in complex mixtures

PA White - Mutation Research/Genetic Toxicology and …, 2002 - Elsevier
Risk assessment of complex environmental samples suffers from difficulty in identifying toxic
components, inadequacy of available toxicity data, and a paucity of knowledge about the …

Polycyclic aromatic hydrocarbons in binary mixtures modulate the efficiency of benzo [a] pyrene to form DNA adducts in human cells

A Tarantini, A Maître, E Lefèbvre, M Marques, A Rajhi… - Toxicology, 2011 - Elsevier
Exposure to polycyclic aromatic hydrocarbons (PAHs) always involves complex mixtures
that may induce synergistic or antagonistic effects on the genotoxic properties and make risk …

Polycyclic aromatic hydrocarbons (PAHs): updated aspects of their determination, kinetics in the human body, and toxicity

F Barbosa Jr, BA Rocha, MCO Souza… - Journal of Toxicology …, 2023 - Taylor & Francis
Polycyclic aromatic hydrocarbons (PAHs) are legacy pollutants of considerable public health
concern. Polycyclic aromatic hydrocarbons arise from natural and anthropogenic sources …

ATSDR evaluation of health effects of chemicals. IV. Polycyclic aromatic hydrocarbons (PAHs): understanding a complex problem

MM Mumtaz, JD George, KW Gold… - Toxicology and …, 1996 - journals.sagepub.com
Polycyclic Aromatic Hydrocarbons (PAHs) are a group of chemicals that are formed during
the incomplete burning of coal, oil, gas, wood, garbage, or other organic substances, such …

The use of toxic equivalency factors in assessing occupational and environmental health risk associated with exposure to airborne mixtures of polycyclic aromatic …

T Petry, P Schmid, C Schlatter - Chemosphere, 1996 - Elsevier
The health risk associated with inhalatory exposure to PAHs either in the occupational
atmosphere or in outdoor air is commonly assessed on the basis of benzo (a) pyrene (BaP) …

Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures

WR Reeves, R Barhoumi, RC Burghardt… - Environmental …, 2001 - ACS Publications
Risk assessments of polycyclic aromatic hydrocarbon mixtures are hindered by a lack of
reliable information on the potency of both mixtures and their individual components. This …

Lung tumorigenic interactions in strain A/J mice of five environmental polycyclic aromatic hydrocarbons.

S Nesnow, MJ Mass, JA Ross, AJ Galati… - Environmental …, 1998 - ehp.niehs.nih.gov
The binary, ternary, quaternary, and quintary interactions of a five-component mixture of
carcinogenic environmental polycyclic aromatic hydrocarbons (PAHs) using response …