Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment
In this review we discuss the effects of exposure to complex PAH mixtures in vitro and in vivo
on mechanisms related to carcinogenesis. Of particular concern regarding exposure to …
on mechanisms related to carcinogenesis. Of particular concern regarding exposure to …
Cancer Risk Assessment of Airborne PAHs Based on in Vitro Mixture Potency Factors
Complex mixtures of polycyclic aromatic hydrocarbons (PAHs) are common environmental
pollutants associated with adverse human health effects including cancer. However, the risk …
pollutants associated with adverse human health effects including cancer. However, the risk …
Binary PAH mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation
YCM Staal, DGAJ Hebels, MH Van Herwijnen… - …, 2007 - academic.oup.com
Polycyclic aromatic hydrocarbons (PAHs) cover a wide range of structurally related
compounds which differ greatly in their carcinogenic potency. PAH exposure usually occurs …
compounds which differ greatly in their carcinogenic potency. PAH exposure usually occurs …
The genotoxicity of priority polycyclic aromatic hydrocarbons in complex mixtures
PA White - Mutation Research/Genetic Toxicology and …, 2002 - Elsevier
Risk assessment of complex environmental samples suffers from difficulty in identifying toxic
components, inadequacy of available toxicity data, and a paucity of knowledge about the …
components, inadequacy of available toxicity data, and a paucity of knowledge about the …
Polycyclic aromatic hydrocarbons in binary mixtures modulate the efficiency of benzo [a] pyrene to form DNA adducts in human cells
A Tarantini, A Maître, E Lefèbvre, M Marques, A Rajhi… - Toxicology, 2011 - Elsevier
Exposure to polycyclic aromatic hydrocarbons (PAHs) always involves complex mixtures
that may induce synergistic or antagonistic effects on the genotoxic properties and make risk …
that may induce synergistic or antagonistic effects on the genotoxic properties and make risk …
Polycyclic aromatic hydrocarbons (PAHs): updated aspects of their determination, kinetics in the human body, and toxicity
Polycyclic aromatic hydrocarbons (PAHs) are legacy pollutants of considerable public health
concern. Polycyclic aromatic hydrocarbons arise from natural and anthropogenic sources …
concern. Polycyclic aromatic hydrocarbons arise from natural and anthropogenic sources …
ATSDR evaluation of health effects of chemicals. IV. Polycyclic aromatic hydrocarbons (PAHs): understanding a complex problem
MM Mumtaz, JD George, KW Gold… - Toxicology and …, 1996 - journals.sagepub.com
Polycyclic Aromatic Hydrocarbons (PAHs) are a group of chemicals that are formed during
the incomplete burning of coal, oil, gas, wood, garbage, or other organic substances, such …
the incomplete burning of coal, oil, gas, wood, garbage, or other organic substances, such …
The use of toxic equivalency factors in assessing occupational and environmental health risk associated with exposure to airborne mixtures of polycyclic aromatic …
T Petry, P Schmid, C Schlatter - Chemosphere, 1996 - Elsevier
The health risk associated with inhalatory exposure to PAHs either in the occupational
atmosphere or in outdoor air is commonly assessed on the basis of benzo (a) pyrene (BaP) …
atmosphere or in outdoor air is commonly assessed on the basis of benzo (a) pyrene (BaP) …
Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures
WR Reeves, R Barhoumi, RC Burghardt… - Environmental …, 2001 - ACS Publications
Risk assessments of polycyclic aromatic hydrocarbon mixtures are hindered by a lack of
reliable information on the potency of both mixtures and their individual components. This …
reliable information on the potency of both mixtures and their individual components. This …
Lung tumorigenic interactions in strain A/J mice of five environmental polycyclic aromatic hydrocarbons.
S Nesnow, MJ Mass, JA Ross, AJ Galati… - Environmental …, 1998 - ehp.niehs.nih.gov
The binary, ternary, quaternary, and quintary interactions of a five-component mixture of
carcinogenic environmental polycyclic aromatic hydrocarbons (PAHs) using response …
carcinogenic environmental polycyclic aromatic hydrocarbons (PAHs) using response …