Reduced social investigation and increased injurious behavior in transgenic 5xFAD mice

F Kosel, JS Hamilton, SL Harrison… - Journal of …, 2021 - Wiley Online Library
Social withdrawal and agitation/aggression are common behavioral and psychological
symptoms of dementia presented by Alzheimer's disease (AD) patients, with males …

Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer's disease

F Kosel, PT Munoz, JR Yang, AA Wong… - Behavioural Brain …, 2019 - Elsevier
In addition to memory impairments, patients with Alzheimer's disease (AD) exhibit a number
of behavioural and psychological symptoms that can affect social interactions over the …

[HTML][HTML] Age-related changes in species-typical behaviours in the 5xFAD mouse model of Alzheimer's disease from 4 to 16 months of age

TP O'Leary, RE Brown - Behavioural Brain Research, 2024 - Elsevier
Alzheimer's disease (AD) patients show age-related decreases in the ability to perform
activities of daily living and the decline in these activities is related to the severity of …

Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer's disease

C Bories, MJ Guitton, C Julien, C Tremblay, M Vandal… - 2012 - journals.plos.org
Besides memory deficits, Alzheimer's disease (AD) patients suffer from neuropsychiatric
symptoms, including alterations in social interactions, which are subject of a growing …

Sex differences in behavior and molecular pathology in the 5XFAD model

A Sil, A Erfani, N Lamb, R Copland… - Journal of …, 2022 - content.iospress.com
Background: The prevalence of Alzheimer's disease (AD) is greater in women compared to
men, but the reasons for this remain unknown. This sex difference has been widely …

Behavioral and EEG changes in male 5xFAD mice

F Schneider, K Baldauf, W Wetzel, KG Reymann - Physiology & behavior, 2014 - Elsevier
Transgenic animal models of Alzheimer's disease (AD) are widely used to investigate
mechanisms of pathophysiology and cognitive dysfunctions. A model with a very early …

Increased aggression in males in transgenic Tg2576 mouse model of Alzheimer's disease

G Alexander, A Hanna, V Serna, L Younkin… - Behavioural brain …, 2011 - Elsevier
Behavioural and psychological signs and symptoms of dementia encompass a wide range
of neuropsychiatric disturbances which coincide with progressing cognitive decline in …

Prolonged isolation stress accelerates the onset of Alzheimer's disease-related pathology in 5xFAD mice despite running wheels and environmental enrichment

JL Peterman, JD White, A Calcagno, C Hagen… - Behavioural Brain …, 2020 - Elsevier
Research has demonstrated that stress can exacerbate AD pathology in transgenic mouse
models of AD. The purpose of the present studies was to extend this work by determining …

Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer's disease

R Keszycki, G Rodriguez, JT Dunn, A Locci… - Neurobiology of …, 2023 - Elsevier
Most patients with Alzheimer's disease (AD) develop neuropsychiatric symptoms (NPS)
alongside cognitive decline, and apathy is one of the most common symptoms. Few …

Aberrant Cortical Activity in 5xFAD Mice in Response to Social and Non-Social Olfactory Stimuli

F Kosel, MR Hartley, TB Franklin - Journal of Alzheimer's …, 2023 - content.iospress.com
Background: Neuroimaging studies investigating the behavioral and psychological
symptoms of dementia (BPSD)—such as apathy, anxiety, and depression—have linked …