Alzheimer's disease (AD) is the most common cause of dementia, characterized by
progressive cognitive decline. The main disease hallmarks include amyloid beta aggregates …

The risk of developing neurodegenerative disorders such as Alzheimer's disease (AD) and
Parkinson's disease (PD) increases with age. AD and PD are the two most common …

Proteomics and metabolomics are two emerging fields that hold promise to shine light on the
molecular mechanisms causing neurodegenerative diseases. Research in this area may …

Alzheimer disease is the most common cause of dementia, yet its clinical diagnosis remains
uncertain until an eventual postmortem histopathology examination. Currently, therapy for …

Neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's
disease (PD) are both characterized by pathogenic protein aggregates that correlate with …

Background: Alzheimer's (AD) and Parkinson's diseases (PD) show deposits of improperly
folded modified proteins. Protein expression mechanisms are involved since the early …

Finding robust biomarkers for Parkinson disease (PD) is currently hampered by inherent
technical limitations associated with imaging or antibody-based protein assays. To …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder accounting for about
50% of all dementias, yet its pathogenic mechanisms remain poorly understood. In order to …

The identification of clinically relevant biomarkers for neurological diseases poses unique
challenges. These include an historical lack of availability of relevant tissues from the site of …

Cognitive impairment, including dementia, is commonly seen in those afflicted with
Parkinson disease (PD), particularly at advanced disease stages. Pathologically, PD with …