We examined the effects of mibefradil, a T-type Ca2+ channel inhibitor, on
voltagedependent K+(Kv) channels in rabbit coronary arterial smooth muscle cells using the …

The antihypertensive agent mibefradil completely and reversibly inhibited T-type calcium
channels in freshly isolated rat cerebellar Purkinje neurons. The potency of mibefradil was …

In the cardiovascular system, two types of voltage‐gated Ca2+ channels are present: the L‐
type and the T‐type. Under normal conditions, T‐type Ca2+ channels are involved in the …

We show that mitogenic cells expressing T-type Ca2+ channels (T-channels) are more
sensitive to the antiproliferative effects of the drugs pimozide and mibefradil than cells …

A novel mibefradil derivative, NNC55-0396, designed to be hydrolysis-resistant, was shown
to be a selective T-type Ca2+ channel inhibitor without L-type Ca2+ channel efficacy …

ABSTRACT NNC 55‐0396 is a structural analog of mibefradil (Ro 40‐5967) that inhibits
both T‐type and high‐voltage‐activated (HVA) Ca2+ channels with a higher selectivity for T …

In contrast to other kinds of voltage-gated Ca2+ channels, the underlying molecular basis of
T-type and R-type channels is not well-understood. To facilitate comparisons with cloned …

In this study, intracellular Ca2+ was measured as the Fura‐2 ratio (R) of fluorescence
excited at 340 and 380 nm (F340/F380) in nonpressurized rat mesenteric small arterioles (Ø …

At supratherapeutic doses (2-to 5-fold), the T-type Ca2+ antagonist mibefradil modifies the
T/U wave of the human ECG. In this study, we show that this effect is observed in conscious …

The actions of the novel calcium (Ca2+) channel antagonist mibefradil (Ro 40–5967), a
selective T-type channel blocker in myocardium, were investigated in embryonic rat spinal …