In mature B cells engagement of the antigen-receptor (BCR) results in a peak of Ca2+ from
mobilisation of internal stores followed by a lower but sustained elevation that is dependent …

Mibefradil is a novel calcium antagonist belonging to a new chemical class of
benzimidazolyl-substituted tetraline derivatives. The safety of mibefradil in patients with mild …

1. The metabolism of mibefradil has been examined in rat, marmoset, cynomolgus monkey
and man after single and multiple oral administration. 2. Metabolites typically represent …

Mibefradil is a novel calcium channel blocker with activity at both L-type and T-type calcium
channels. There are data suggesting that this compound can protect the …

The effect of 20 mmextracellularly applied 2, 3-Butanedione monoxime (BDM) onl-type
Ca2+ channel charge movement current was studied in whole-cell voltage-clamped guinea …

Regulation of the kinetics of intracellular Ca2+ signals with a novel, membrane-penetrable,
inositol 1, 4, 5-trisphosphate (InsP3) receptor/Ca2+ channel modulator, 2-amino …

In the search for a readily available source of native cardiac cells, we investigated the
molecular and pharmacological properties of the immortalized cardiac atrial myocyte cell …

Mefenamic acid as a novel activator of L-type voltage-dependent Ca2+ channels in smooth
muscle cells from pig proximal urethra - PMC Back to Top Skip to main content NIH NLM Logo …

Preclinical and initial clinical studies suggest that the novel calcium antagonist mibefradil
has a unique combination of properties. Mibefradil was evaluated in a multicenter, double …

The compound 2-aminoethoxydiphenyl borate (2-APB) has been used as either a specific
membrane-permeable inhibitor for InsP 3 receptors or a store-operated Ca 2+ channel …