The field of molecular epidemiology of aging involves the application of molecular methods
to measure aging processes and their genetic determinants in human cohorts. Over the last …

Human lifespan variation is mainly determined by environmental factors, whereas the
genetic contribution is 25–30% and expected to be polygenic. Two complementary fields go …

The first clinical trial aimed at targeting fundamental processes of aging will soon be
launched (TAME: Targeting Aging with Metformin). In its wake is a robust pipeline of …

The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

The application of high-throughput technologies to aging-related research has the potential
to dramatically enhance our understanding of how longevity is determined at a molecular …

As healthspan and lifespan research breakthroughs have become more commonplace, the
need for valid, practical markers of biological age is becoming increasingly paramount. The …

Leading biologists and clinicians interested in aging convened to discuss biomarkers of
aging. The goals were to come to a consensus, construct an agenda for future research, and …

Much progress has been made in the past decades in unraveling the mechanisms that are
responsible for aging. The discovery that particular gene mutations in experimental species …

Biologic aging reflects the genetic, molecular, and cellular changes underlying the
development of morbidity and mortality with advancing chronological age. As several …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …