Windows of plasticity allow environmental experiences to produce intense activity-
dependent changes during postnatal development. The reordering and refinement of neural …

Mice lacking a synaptic isoform of glutamic acid decarboxylase (GAD65) do not exhibit
ocular dominance plasticity unless an appropriate level of GABAergic transmission is …

Is a dog ever too old to learn new tricks? We review recent findings on sensitive periods in
brain development, ranging from sensory processing to high-level cognitive abilities in …

Proper wiring of neural circuits during development depends on both molecular cues that
guide connectivity and activity-dependent mechanisms that use patterned activation to …

During sensitive and critical periods, the brain undergoes significant plasticity from the level
of individual synapses and neuronal networks up to the level of behaviour. Both sensitive …

Inhibitory control requires precise regulation of activity and connectivity within multiple brain
networks. Previous studies have typically evaluated age-related changes in regional activity …

Sensory experience is crucial for shaping the cortical microcircuit during development and is
thought to modify network function through several forms of Hebbian and homeostatic …

An essential feature of the brain is its capacity to change. Neuroscientists use the term
'plasticity'to describe the malleability of neuronal connectivity and circuitry. How does …

Brain plasticity, defined as the capability of cerebral neurons to change in response to
experience, is fundamental for behavioral adaptability, learning, memory, functional …

Circadian rhythms control a variety of physiological processes, but whether they may also
time brain development remains largely unknown. Here, we show that circadian clock genes …