A crucial issue in neurobiology is to understand the main mechanisms restricting neural
plasticity to brief windows of early postnatal life. The visual system is one of the paradigmatic …

The mechanisms underlying experience-dependent plasticity and refinement of central
circuits are not yet fully understood. A non-Hebbian form of synaptic plasticity, which scales …

Throughout development, the brain transits from early highly synchronous activity patterns to
a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying …

Environmental enrichment potentiates neural plasticity, enhancing acquisition and
consolidation of memory traces. In the sensory cortices, after cortical circuit maturation and …

Neuronal circuits across several systems display remarkable plasticity to sensory input
during postnatal development,,,,,,,,,. Experience-dependent refinements are often restricted …

Spike-timing dependent plasticity (STDP) offers a powerful means of forming and modifying
neural circuits. Experimental and theoretical studies have demonstrated its potential …

For proper maturation of the neocortex and acquisition of specific functions and skills,
exposure to sensory stimuli is vital during critical periods of development when synaptic …

Nervous system development proceeds by sequential gene expression mediated by
cascades of transcription factors in parallel with sequences of patterned network activity …

Sensory experience in early postnatal life, during so-called critical periods, restructures
neural circuitry to enhance information processing. Why the cortex is susceptible to sensory …