At present, no large randomized controlled trial has been performed in patients undergoing
major noncardiac surgery. However, despite the widespread use of corticosteroids to …

Objective Corticosteroids can attenuate the inflammatory response to cardiopulmonary
bypass, but their benefits on clinical outcomes are unclear. We conducted a meta-analysis to …

Background Glucocorticoids are increasingly used perioperatively, principally to prevent
nausea and vomiting. Safety concerns focus on the potential for hyperglycemia and …

With complex and extensive pharmacological effects, corticosteroids are widely used in
many clinical situations. A survey conducted to define the role of corticosteroids in various …

From the early publications on the use of corticosteroids in infection, 1 our understanding of
their pharmacology and mode of actions has improved. Clinicians progressively have …

Background Perioperative glucocorticoid supplementation has been suggested as a
potentially effective precaution against perioperative adrenal crisis in patients on long-term …

Corticosteroids are commonly used in the peri-operative setting for patients undergoing
cardiac surgery with cardiopulmonary bypass (CPB). The inflammatory response to CPB is …

METHODS A Medline search (1966 to May 2001) was performed to identify all randomized,
clinical trials published in English-language journals, in which a single dose of GC was …

Corticosteroid use is common, with 8.4 million UK prescriptions issued for oral preparations
in 2018 [1]. They are prescribed as replacements for deficiency as well as therapeutically for …

Background: A single preoperative high dose of methylprednisolone (15 to 30 mg/kg) has
been advocated in surgery, because it may inhibit the surgical stress response and thereby …