Increasing the chemical variety of small-molecule-based TLR4 modulators: An overview
Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by
Pathogen-and Damage-Associated Molecular Patterns (PAMPs and DAMPs) and triggers …
Pathogen-and Damage-Associated Molecular Patterns (PAMPs and DAMPs) and triggers …
Recent advances on Toll-like receptor 4 modulation: new therapeutic perspectives
L Zaffaroni, F Peri - Future medicinal chemistry, 2018 - Taylor & Francis
Activation or inhibition of TLR4 by small molecules will provide in the next few years a new
generation of therapeutics. TLR4 stimulation (agonism) by high-affinity ligands mimicking …
generation of therapeutics. TLR4 stimulation (agonism) by high-affinity ligands mimicking …
Toll-like receptor 4 (TLR4) modulation by synthetic and natural compounds: an update: miniperspective
F Peri, V Calabrese - Journal of medicinal chemistry, 2014 - ACS Publications
Toll-like receptor 4 (TLR4), together with MD-2, binds bacterial endotoxins (E) with high
affinity, triggering formation of the activated homodimer (E. MD-2. TLR4) 2. Activated TLR4 …
affinity, triggering formation of the activated homodimer (E. MD-2. TLR4) 2. Activated TLR4 …
Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective
Y Zhang, X Liang, X Bao, W Xiao, G Chen - European journal of medicinal …, 2022 - Elsevier
Abstract Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is
involved in innate immunity and mediates inflammatory responses by recognizing …
involved in innate immunity and mediates inflammatory responses by recognizing …
Small molecule agonists of toll-like receptors 7 and 8: a patent review 2014–2020
ME Kieffer, AM Patel, SA Hollingsworth… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Toll-like receptors 7 and 8 (TLR7 and TLR8) are endosomal immune receptors
that initiate an innate immune response and can facilitate activation of the adaptive immune …
that initiate an innate immune response and can facilitate activation of the adaptive immune …
Small-molecule modulators of toll-like receptors
Conspectus Toll-like receptors (TLRs) are the “gatekeepers” of the immune system in
humans and other animals to protect the host from invading bacteria, viruses, and other …
humans and other animals to protect the host from invading bacteria, viruses, and other …
Small-molecule TLR8 antagonists via structure-based rational design
Rational design of drug-like small-molecule ligands based on structural information of
proteins remains a significant challenge in chemical biology. In particular, designs targeting …
proteins remains a significant challenge in chemical biology. In particular, designs targeting …
Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists
F Peri, M Piazza - Biotechnology advances, 2012 - Elsevier
Early recognition of invading bacteria by the innate immune system has a crucial function in
antibacterial defense by triggering inflammatory responses that prevent the spread of …
antibacterial defense by triggering inflammatory responses that prevent the spread of …
TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis
NN Kuzmich, KV Sivak, VN Chubarev, YB Porozov… - Vaccines, 2017 - mdpi.com
Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate
immune response and its activation by bacterial endotoxin is responsible for chronic and …
immune response and its activation by bacterial endotoxin is responsible for chronic and …
Therapeutic targeting of TLR4 for inflammation, infection, and cancer: a perspective for disaccharide lipid A mimetics
H Heine, A Zamyatina - Pharmaceuticals, 2022 - mdpi.com
The Toll-like receptor 4 (TLR4) signaling pathway plays a central role in the prompt defense
against infectious challenge and provides immediate response to Gram-negative bacterial …
against infectious challenge and provides immediate response to Gram-negative bacterial …