[HTML][HTML] PPARadigms and PPARadoxes: expanding roles for PPARγ in the control of lipid metabolism

R Walczak, P Tontonoz - Journal of lipid research, 2002 - ASBMB
The nuclear receptor PPARγ is a central regulator of adipose tissue development and an
important modulator of gene expression in a number of specialized cell types including …

Peroxisome proliferator–activated receptor γ and metabolic disease

TM Willson, MH Lambert… - Annual review of …, 2001 - annualreviews.org
▪ Abstract The nuclear peroxisome proliferator–activated receptor γ (PPARγ) is a
transcription factor that is activated by polyunsaturated fatty acids and their metabolites and …

PPARγ2Pro12Ala Polymorphism and Human Health

W He - PPAR research, 2009 - Wiley Online Library
The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPARγ) is
an important transcription factor regulating adipocyte differentiation, lipid and glucose …

Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity.

BM Spiegelman - European journal of medical research, 1997 - europepmc.org
The adipose cell is now known to play a complex role in energy homeostasis, storing energy
and signaling to other tissues concerning the state of energy balance. The past several …

PPARγ and metabolism: insights from the study of human genetic variants

M Gurnell - Clinical endocrinology, 2003 - Wiley Online Library
Diabetes, obesity, atherosclerosis and cancer are the principal contributors to morbidity and
mortality in Western society. Emerging evidence indicates that a nuclear receptor, the …

[HTML][HTML] PPARγ and human metabolic disease

RK Semple, VKK Chatterjee… - The Journal of clinical …, 2006 - Am Soc Clin Investig
The nuclear receptor family of PPARs was named for the ability of the original member to
induce hepatic peroxisome proliferation in mice in response to xenobiotic stimuli. However …

The role of PPARγ in high-fat diet-induced obesity and insulin resistance

T Kadowaki, K Hara, N Kubota, K Tobe… - Journal of diabetes and …, 2002 - Elsevier
It has been well demonstrated that insulin resistance plays an important role in the clustering
of coronary risk factors through the progression of atherosclerosis in animal models of …

Peroxisome proliferator-activated receptor (PPAR) β/δ: a new potential therapeutic target for the treatment of metabolic syndrome

T Coll, R Rodríguez-Calvo, E Barroso… - Current molecular …, 2009 - ingentaconnect.com
Metabolic syndrome is defined as the clustering of multiple metabolic abnormalities,
including abdominal obesity, dyslipidemia (high serum triglycerides and low serum HDL …

Peroxisome proliferator-activated receptor δ: a multifaceted metabolic player

LA Bojic, MW Huff - Current opinion in lipidology, 2013 - journals.lww.com
Peroxisome proliferator-activated receptor δ: a multifaceted... : Current Opinion in Lipidology
Peroxisome proliferator-activated receptor δ: a multifaceted metabolic player : Current Opinion …

[HTML][HTML] Deciphering the roles of PPARγ in adipocytes via dynamic change of transcription complex

X Ma, D Wang, W Zhao, L Xu - Frontiers in endocrinology, 2018 - frontiersin.org
Peroxisome proliferator-activated receptor γ (PPARγ), a ligand-dependent transcription
factor highly expressed in adipocytes, is a master regulator of adipogenesis and lipid …