This study examined the influence of environmental enrichment on the behavioral response
to amphetamine. Beginning at 21 days of age, rats were raised in one of three different …

Rationale: Previous work has shown that environmental enrichment alters amphetamine-
induced locomotor activity and conditioned place preference. Objective: The present study …

Until recently, most modern neuroscience research on addiction using animal models did
not incorporate manipulations of social factors. Social factors play a critical role in human …

Food restriction has been shown to increase self‐administration of psychostimulants,
including cocaine and amphetamine (AMPH). Consistent with this, food‐restricted rats are …

BACKGROUND: The conditioned place preference procedure is a widely used animal
model of rewarding drug effects that, to date, has not been tested in humans. In this study …

Neural and physiological factors underlying individual differences in the vulnerability to drug
abuse are the major questions remained to be determined. The present study described …

Impaired social interaction is a hallmark symptom of many psychiatric disorders. In
substance use disorders, impaired social interaction is triply harmful (a) because addicts …

Whereas earlier studies have focused on the preventive effects of enriched environments
(EE) in drug addiction, in a recent study we suggested that EE can also have …

Background Previous studies found that environmental enrichment protects against the
initiation of stimulant self-administration in rats, but it is unclear if enrichment also protects …

A major concern in adolescent psychostimulant abuse is the long-term consequence of this
practice, because early drug exposure may cause long-term adaptations, which render the …