We previously reported that chronic social stress (SS) in adolescence, but not in adulthood,
increased the locomotor‐activating effects of nicotine in females, and not males, when tested …

High locomotor response to novelty is associated with ease of drug self-administration but
does not predict greater place-conditioning effects of drugs. Yet, the latter reflects context …

Rationale Age of initial exposure to addictive substances is inversely proportional to risk of
developing drug dependence. There is debate, however, as to whether intake at a young …

Rationale: Among the various experimental protocols that have been used to measure drug
reward in laboratory animals, conditioned place preference (CPP) has been one of the most …

In addition to the known preventive effects of environmental enrichment (EE) on drug
addiction, we have recently shown that EE can also have “curative” effects and eliminate …

Adolescent cocaine use increases the likelihood of drug abuse and addiction in adulthood,
and etiological factors may include a cocaine-induced bias towards so-called 'reward …

Environmental conditions can dramatically influence the behavioral and neurochemical
effects of drugs of abuse. For example, stress increases the reinforcing effects of drugs and …

Rationale Previous studies have shown that environmental context can powerfully modulate
the induction of psychomotor sensitization to cocaine in the rat. Rats that receive repeated …

Repeated exposure to drugs of abuse produces forms of experience-dependent plasticity
including behavioral sensitization. Although a single exposure to many addicting …

The conditioned place preference (CPP) procedure is a popular method used for testing the
rewarding properties of human drugs of abuse. Most CPP studies utilize mammalian …