Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related
progressive disease characterized by reduced bone mass and increased risk of fractures. At …

Aging is associated with decreased bone mass and accumulation of bone marrow
adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived …

Osteoblasts and adipocytes originate from a common progenitor, which arises from bone
marrow mesenchymal stroma/stem cells (mMSC). Aging causes a decrease in the number of …

Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

The aging population and the incidence of aging-related diseases such as osteoporosis are
on the rise. Aging at the tissue and organ levels usually involves tissue stem cells. Human …

Mesenchymal stem cells (MSC) have attracted considerable attention in the fields of cell and
gene therapy due to their intrinsic ability to differentiate into multiple lineages. The various …

In the adult bone marrow, osteoblasts and adipocytes share a common precursor called
mesenchymal stem cells (MSCs). The plasticity between the two lineages has been …

The formation, maintenance, and repair of bone tissue involve close interlinks between two
stem cell types housed in the bone marrow: the hematologic stem cell originating …

Osteoporosis is caused by pathologic factors such as aging, hormone deficiency or excess,
inflammation and systemic diseases like diabetes. Bone marrow stromal cells (BMSCs), the …

This review focuses on the osteogenic differentiation of mesenchymal stem cells (MSC),
bone formation and turn-over in good and ill skeletal fates. The interacting molecular …