Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model

J Long, H Gao, L Sun, J Liu… - Rejuvenation research, 2009 - liebertpub.com
A botanical extract (Regrapex-R®) prepared from whole grape (Vitis vinifera) and
Polygonum cuspidatum, which contains polyphenols, including flavans, anthocyanins …

Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson's disease through activation of mitophagy

Z Wu, A Wu, J Dong, A Sigears, B Lu - Experimental gerontology, 2018 - Elsevier
Recent studies suggest that moderate red wine consumption may confer several health
benefits, including protection against heart disease, certain cancers and multiple age …

Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia

S Yousuf, F Atif, M Ahmad, N Hoda, T Ishrat, B Khan… - Brain research, 2009 - Elsevier
Free radicals are known to cause secondary neuronal damage in cerebral
ischemia/reperfusion (I/R). We investigated here the neuroprotective effect of resveratrol, a …

Resveratrol and/or exercise training counteract aging-associated decline of physical endurance in aged mice; targeting mitochondrial biogenesis and function

MH Muhammad, MM Allam - The Journal of Physiological Sciences, 2018 - Springer
Mitochondrial dysfunction and decreased mitochondrial content are hallmarks of aging that
leads to decreased physical endurance. Our aim was to explore the anti-aging effect of …

Resveratrol-induced limitation of dysfunction of mitochondria isolated from rat brain in an anoxia-reoxygenation model

R Zini, C Morin, A Bertelli, AAE Bertelli, JP Tillement - Life sciences, 2002 - Elsevier
Resveratrol protection on the main functions of purified rat brain mitochondria submitted to
anoxia-reoxygenation was investigated. Resveratrol (< 0.1 μM) reversed partly (23.3%) the …

Resveratrol and brain mitochondria: a review

FR Jardim, FT de Rossi, MX Nascimento… - Molecular …, 2018 - Springer
Abstract Resveratrol (3, 4', 5-trihydroxystilbene; C 14 H 12 O 3) is a polyphenolic phytoalexin
found in grapes, berries, peanuts, and wines. Resveratrol has been viewed as an …

Resveratrol affects differently rat liver and brain mitochondrial bioenergetics and oxidative stress in vitro: investigation of the role of gender

AC Moreira, AM Silva, MS Santos, VA Sardão - Food and chemical …, 2013 - Elsevier
Resveratrol (3, 5, 4′-trihydroxy-trans stilbene) is commonly recognized by its antioxidant
properties. Despite its beneficial qualities, the toxic effects of this natural compound are still …

Grape seed proanthocyanidin lowers brain oxidative stress in adult and middle-aged rats

SA Devi, BKS Chandrasekar, KR Manjula… - Experimental …, 2011 - Elsevier
There is growing concern over the increasing instances of decline in cognitive abilities with
aging in humans. The present study evaluated the benefits of the natural antioxidant, grape …

[HTML][HTML] Signaling mechanisms underlying the glioprotective effects of resveratrol against mitochondrial dysfunction

B Bellaver, LD Bobermin, DG Souza… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Resveratrol, a polyphenol found in grapes and red wine, exhibits antioxidant, anti-
inflammatory, anti-aging and, neuroprotective effects. Resveratrol also plays a significant …

Protective Effects of Salidroside in the MPTP/MPP+-Induced Model of Parkinson's Disease through ROS–NO-Related Mitochondrion Pathway

S Wang, H He, L Chen, W Zhang, X Zhang… - Molecular neurobiology, 2015 - Springer
Parkinson's disease is a progressive neurodegenerative disease causing tremor, rigidity,
bradykinesia, and gait impairment. Oxidative stress and mitochondrial dysfunction play …