[HTML][HTML] Long-term ex vivo expansion of mouse hematopoietic stem cells

AC Wilkinson, R Ishida, H Nakauchi, S Yamazaki - Nature protocols, 2020 - nature.com
Utilizing multipotent and self-renewing capabilities, hematopoietic stem cells (HSCs) can
maintain hematopoiesis throughout life. However, the mechanism behind such remarkable …

[HTML][HTML] Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation

AC Wilkinson, R Ishida, M Kikuchi, K Sudo, M Morita… - Nature, 2019 - nature.com
Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the adult blood
system after transplantation, which is a curative therapy for numerous diseases including …

[HTML][HTML] In vitro human haematopoietic stem cell expansion and differentiation

YK Bozhilov, I Hsu, EJ Brown, AC Wilkinson - Cells, 2023 - mdpi.com
The haematopoietic system plays an essential role in our health and survival. It is comprised
of a range of mature blood and immune cell types, including oxygen-carrying erythrocytes …

[HTML][HTML] Chemically defined cytokine-free expansion of human haematopoietic stem cells

M Sakurai, K Ishitsuka, R Ito, AC Wilkinson, T Kimura… - Nature, 2023 - nature.com
Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and
immune systems after transplantation and can be used as a curative cell therapy for a variety …

[HTML][HTML] Adult mouse hematopoietic stem cells: purification and single-cell assays

H Ema, Y Morita, S Yamazaki, A Matsubara, J Seita… - Nature protocols, 2006 - nature.com
Mouse hematopoietic stem cells (HSCs) are the best-studied stem cells because functional
assays for mouse HSCs were established earliest and purification techniques for mouse …

[HTML][HTML] Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells

R Yamamoto, Y Morita, J Ooehara, S Hamanaka… - Cell, 2013 - cell.com
Consensus holds that hematopoietic stem cells (HSCs) give rise to multipotent progenitors
(MPPs) of reduced self-renewal potential and that MPPs eventually produce lineage …

Hematopoietic stem cell expansion: challenges and opportunities

MA Walasek, R van Os… - Annals of the New York …, 2012 - Wiley Online Library
Attempts to improve hematopoietic reconstitution and engraftment potential of ex vivo–
expanded hematopoietic stem and progenitor cells (HSPCs) have been largely …

Little evidence for developmental plasticity of adult hematopoietic stem cells

AJ Wagers, RI Sherwood, JL Christensen, IL Weissman - Science, 2002 - science.org
To rigorously test the in vivo cell fate specificity of bone marrow (BM) hematopoietic stem
cells (HSCs), we generated chimeric animals by transplantation of a single green …

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

K Busch, K Klapproth, M Barile, M Flossdorf… - Nature, 2015 - nature.com
Haematopoietic stem cells (HSCs) are widely studied by HSC transplantation into immune-
and blood-cell-depleted recipients. Single HSCs can rebuild the system after …

[HTML][HTML] Unperturbed vs. post-transplantation hematopoiesis: both in vivo but different

K Busch, HR Rodewald - Current opinion in hematology, 2016 - journals.lww.com
Unperturbed vs. post-transplantation hematopoiesis: both in... : Current Opinion in Hematology
Unperturbed vs. post-transplantation hematopoiesis: both in vivo but different : Current Opinion …