Objective Fibrosis is excessive scarring caused by the accumulation and contraction of
extracellular matrix proteins and is a common end pathway in many chronic diseases …

Background We have reported that heparin-binding epidermal growth factor (HB-EGF) is
increased in patients with chronic obstructive pulmonary disease (COPD) and associated …

Idiopathic pulmonary fibrosis is characterized by myofibroblast accumulation, extracellular
matrix (ECM) remodeling, and excessive collagen deposition. ECM‐producing …

Background Fibroblastic foci are characteristic features in lung parenchyma of patients with
idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which …

Idiopathic Pulmonary Fibrosis (IPF) is characterized by injury and loss of lung epithelial
cells, accumulation of fibroblasts/myofibroblasts and abnormal remodeling of the lung …

The response of alveolar epithelial cells (AECs) to lung injury plays a central role in the
pathogenesis of pulmonary fibrosis, but the mechanisms by which AECs regulate fibrotic …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by lung
inflammation and excessive deposition of extracellular matrix components. Transforming …

The molecular basis of airway remodeling and loss of epithelial integrity in asthma is still
undefined. We aimed to establish if exposure of human bronchial epithelium (16HBE cells) …

Purpose: Steroid hormones and growth factors affect lung cancer, and it is possible they act
in concert to influence patient outcome. Experimental Design: Primary lung tumors and …

Background: Airway remodeling is an important feature of chronic airway disease, but the
mechanisms involved remain unclear. Recently, epithelial mesenchymal transition (EMT) …