Pharmacophore mapping is one of the major elements of drug design in the absence of
structural data of the target receptor. The tool initially applied to discovery of lead molecules …

Pharmacophore discovery is one of the major elements of molecular modeling in the
absence of X-ray structural data. While pharmacophores initially made their debut as a …

With computer-aided drug design established as an integral part of the lead discovery and
optimization process, pharmacophores have become a focal point for conceptualizing and …

This review summarizes the background and updated progress of pharmacophore based
drug design and provides the fundamental approach strategies on both structure based and …

Pharmacophore approaches have become one of the major tools in drug discovery after the
past century's development. Various ligand-based and structure-based methods have been …

Although the terms molecular alignment and superposition and pharmacophore elucidation
are often used interchangeably, it is probably more accurate to differentiate alignment as …

We introduce PHASE, a highly flexible system for common pharmacophore identification
and assessment, 3D QSAR model development, and 3D database creation and searching …

Pharmacophore-based techniques currently are an integral part of many computer-aided
drug design workflows and have been successfully and extensively applied for tasks such …

Pharmacophore modeling is a successful yet very diverse subfield of computer-aided drug
design. The concept of the pharmacophore has been widely applied to the rational design of …

In this chapter we review the use of 3-D pharmacophores in drug discovery. Recent
advances are highlighted, including the application of pharmacophore descriptors …