Novel fluorescently-labeled conjugates of risedronate were synthesized using an epoxide
linker, enabling conjugation of risedronate via its pyridyl nitrogen with the aromatic …

Bioluminescence (BL) is broadly used as an optical readout in bioassays and molecular
imaging. In this study, the near-infrared (NIR) BL imaging systems were developed. The …

Currently, natural products are one of the priceless options for finding novel chemical
pharmaceutical entities. Ellipticine is a naturally occurring alkaloid isolated from the leaves …

To study the target proteins of oleanolic acid, a series of novel photoaffinity probes were
designed and synthesized. Their affinity for the target proteins was evaluated in an enzyme …

Thalidomide and its derivatives were drawing attentions as an old drug since the cereblon
(CRBN) as a thalidomide-binding protein was identified. Herein, we reported its novel …

A novel dual-mode fluorescence “turn-on” probe is developed based on a phosphorylated
tetraphenylethene (TPE) derivative bearing aggregation-induced emission (AIE) …

Abstract Z-ligustilide (LIG), an essential oil extract from Radix Angelica sinensis, has broad
pharmaceutical applications in treating cardiovascular and cerebrovascular diseases …

Alkaline phosphatase (ALP) is an important biomarker in clinical diagnostics, and the
abnormal level of ALP enzyme in serum is closely related to various diseases such as bone …

The direct determination of alogliptin benzoate (ALO) using fluorescence has not yet been
accomplished because ALO cannot fluoresce naturally. Accordingly, it should be derivatized …

Leucine aminopeptidase (LAP) as an important proteolytic enzyme, has been mainly found
in hepatobiliary cells, and overexpressed in hepatoma cells. Herein, a new highly selective …