Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …
molecular underpinnings of this variability is of great relevance for developing individualized …
FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior
C Touma, NC Gassen, L Herrmann, J Cheung-Flynn… - Biological …, 2011 - Elsevier
BACKGROUND: The Hsp90 cochaperone FK506 binding protein 5 (FKBP5) is an
established regulator of the glucocorticoid receptor (GR), and numerous genetic studies …
established regulator of the glucocorticoid receptor (GR), and numerous genetic studies …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency
Single nucleotide polymorphisms (SNPs) in the FK506 binding protein 5 (FKBP5) gene
combine with traumatic events to increase risk for post-traumatic stress and major …
combine with traumatic events to increase risk for post-traumatic stress and major …
Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism
Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
Expression and Regulation of the Fkbp5 Gene in the Adult Mouse Brain
SH Scharf, C Liebl, EB Binder, MV Schmidt, MB Müller - PloS one, 2011 - journals.plos.org
Background Chronic stress has been found to be a major risk factor for various human
pathologies. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which is tightly …
pathologies. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which is tightly …
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice
AS Häusl, LM Brix, J Hartmann, ML Pöhlmann… - Molecular …, 2021 - nature.com
Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-
adrenal (HPA) axis is a fundamental component of multiple stress-related diseases …
adrenal (HPA) axis is a fundamental component of multiple stress-related diseases …
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …
development and function of the human brain and, ultimately, the risk of psychiatric …
The prospect of FKBP51 as a drug target
MV Schmidt, M Paez‐Pereda, F Holsboer… - …, 2012 - Wiley Online Library
The FK506 binding protein 51 (FKBP51) is best known as an Hsp90‐associated co‐
chaperone that regulates the responsiveness of steroid hormone receptors. In human …
chaperone that regulates the responsiveness of steroid hormone receptors. In human …
Hsp90 and FKBP51: complex regulators of psychiatric diseases
M Criado-Marrero, T Rein… - … of the Royal …, 2018 - royalsocietypublishing.org
Mood disorders affect nearly a quarter of the world's population. Therefore, understanding
the molecular mechanisms underlying these conditions is of great importance. FK-506 …
the molecular mechanisms underlying these conditions is of great importance. FK-506 …