We have developed a practical method for the comprehensive analysis of polar anionic
metabolites in biological samples with the use of a nano-LC/MS system. A polyamine …

Reversed-phase (RP) nanoliquid chromatography (LC)/mass spectrometry (MS) is widely
used for proteome analysis, but hydrophilic metabolites are poorly retained on RP columns …

We describe a sheath flow capillary electrophoresis time-of-flight mass spectrometry (CE-
TOFMS) method in the negative mode using a platinum electrospray ionization (ESI) spray …

One of the technical challenges in the field of metabolomics is the development of a single-
run method to detect the full complement of polar metabolites in biological samples …

The metabolome is the complete set of small molecules coming from protein activity
(anabolism and catabolism) in living systems. They have a broad range of chemical …

Capillary liquid chromatography coupled with electrospray ionization to a quadrupole ion
trap mass spectrometer was explored as a method for the analysis of polar anionic …

The effective analysis of polar ionic metabolites by LC–MS, such as those encountered in
central carbon metabolism, represents a major problem for metabolic profiling that is not …

The efficient profiling of highly polar and charged metabolites in biological samples remains
a huge analytical challenge in metabolomics. Over the last decade, new analytical …

Use of silica stationary phase and aqueous–organic mobile phases could significantly
enhance LC–MS–MS method sensitivity. The LC conditions were compatible with MS …

The tandem use of hydrophilic interaction LC columns with RP columns in series
configuration has resulted in the retention of both polar and nonpolar components in …