Macrophages are prevalent in the body and have roles in almost every aspect of human
biology. They have often been considered a subject to avoid during drug delivery. However …

Macrophages have been extensively used in the development of drug delivery systems, as
they can prolong the circulation and release of drugs, extend their half-life, increase their …

Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Introduction: Targeted drug delivery to the macrophages appears to be an attractive
proposition to improve therapeutic efficacy of enclosed drug. Thus, macrophages can be …

Macrophages play a crucial role in tissue homeostasis and the innate immune system. They
perform essential functions such as presenting antigens, regulating cytokines, and …

With the effectiveness of therapeutic agents ever decreasing and the increased incidence of
multi-drug resistant pathogens, there is a clear need for administration of more potent …

Heterogeneous functions of macrophages in human immune systems have renewed interest
in targeting of drugs to these cells. Various carrier systems have emerged to deliver drugs to …

Introduction: Drug targeting to sites of tissue injury, tumor or infection with limited toxicity is
the goal for successful pharmaceutics. Immunocytes (including mononuclear phagocytes …

As the role of monocytes and macrophages in a range of diseases is better understood,
strategies to target these cell types are of growing importance both scientifically and …

For over a century, researchers have focused on how to optimize drug delivery. Systemic
administration means that the drug becomes dilute and has the potential to diffuse to all …