[HTML][HTML] Trehalose is a versatile and long-lived chaperone for desiccation tolerance

H Tapia, DE Koshland - Current Biology, 2014 - cell.com
Background Diverse organisms across taxa are desiccation tolerant, capable of surviving
extreme water loss. Remarkably, desiccation tolerant organisms can survive years without …

Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae

H Tapia, L Young, D Fox… - Proceedings of the …, 2015 - National Acad Sciences
Diverse organisms capable of surviving desiccation, termed anhydrobiotes, include species
from bacteria, yeast, plants, and invertebrates. However, most organisms are sensitive to …

[HTML][HTML] Intracellular trehalose improves osmotolerance but not desiccation tolerance in mammalian cells

AG de Castro, A Tunnacliffe - FEBS letters, 2000 - Elsevier
Trehalose has been shown to play a role in osmotolerance or desiccation tolerance in some
microorganisms, anhydrobiotic invertebrates and resurrection plants. To test whether …

[HTML][HTML] Trehalose and tardigrade CAHS proteins work synergistically to promote desiccation tolerance

K Nguyen, S Kc, T Gonzalez, H Tapia… - Communications …, 2022 - nature.com
Tardigrades are microscopic animals renowned for their ability to survive extreme
desiccation. Unlike many desiccation-tolerant organisms that accumulate high levels of the …

[HTML][HTML] New insight into the mechanisms protecting bacteria during desiccation

E Laskowska, D Kuczyńska-Wiśnik - Current genetics, 2020 - Springer
Desiccation is a common stress that bacteria face in the natural environment, and thus, they
have developed a variety of protective mechanisms to mitigate the damage caused by water …

Genetic Analysis of Desiccation Tolerance in Saccharomyces cerevisiae

D Calahan, M Dunham, C DeSevo, DE Koshland - Genetics, 2011 - academic.oup.com
Desiccation tolerance, the ability to survive nearly total dehydration, is a rare strategy for
survival and reproduction observed in all taxa. However, the mechanism and regulation of …

Anhydrobiotic engineering of bacterial and mammalian cells: is intracellular trehalose sufficient?

A Tunnacliffe, AG de Castro, M Manzanera - Cryobiology, 2001 - Elsevier
Anhydrobiotic engineering aims to confer a high degree of desiccation tolerance on
otherwise sensitive living organisms and cells by adopting the strategies of anhydrobiosis …

Trehalose is required for conformational repair of heat‐denatured proteins in the yeast endoplasmic reticulum but not for maintenance of membrane traffic functions …

M Simola, AL Hänninen, SM Stranius… - Molecular …, 2000 - Wiley Online Library
Saccharomyces cerevisiae cells grown at physiological temperature 24° C require
preconditioning at 37° C to acquire tolerance towards brief exposure to 48–50° C. During …

Intracellular trehalose is neither necessary nor sufficient for desiccation tolerance in yeast

S Ratnakumar, A Tunnacliffe - FEMS yeast research, 2006 - academic.oup.com
Trehalose is thought to be important for desiccation tolerance in a number of organisms,
including Saccharomyces cerevisiae, but there is limited in vivo evidence to support this …

[HTML][HTML] Multiple effects of trehalose on protein folding in vitro and in vivo

MA Singer, S Lindquist - Molecular cell, 1998 - cell.com
The disaccharide trehalose is produced in large quantities by diverse organisms during a
variety of stresses. Trehalose prevents proteins from denaturing at high temperatures in …