Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths
worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments …

The insulin-like growth factor (IGF) axis contains ligands, receptors, substrates, and ligand
binding proteins. The essential role of IGF axis in hepatocellular carcinoma (HCC) has been …

Constitutive activation of the insulin-like growth factor (IGF)-signaling axis is frequently
observed in human hepatocellular carcinoma (HCC). Especially the overexpression of the …

BACKGROUND & AIMS: IGF signaling has a relevant role in a variety of human
malignancies. We analyzed the underlying molecular mechanisms of IGF signaling …

Primary hepatocellular carcinoma (HCC) is one of the most common forms of malignant
cancer with the fourth highest mortality rate worldwide. Major risk factors for the development …

Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem
cell pluripotency and differentiation to trigger cell proliferation, organ development, and …

Purpose: The insulin-like growth factor (IGF) signaling axis is frequently dysregulated in
hepatocellular carcinoma (HCC). Therefore, we investigated whether the specific targeting …

Molecular subtyping of human hepatocellular carcinoma (HCC) with potential mechanistic
and therapeutic impact has not been achieved thus far. We have analyzed the mRNA …

Hepatocellular carcinoma (HCC) is a common malignancy, but treatment outcomes have
generally remained poor. Specific factors important for the pathogenesis of HCC are …

Background & Aims Effective treatments are urgently needed for hepatocellular carcinoma
(HCC), which is usually diagnosed at advanced stages. Signaling via the insulin-like growth …