DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful
duplication of our genomes, mechanisms have evolved to deal with damage encountered …

Accurate DNA replication is crucial for cell survival and the maintenance of genome stability.
Cells have developed mechanisms to cope with the frequent genotoxic injuries that arise …

DNA damage may compromise genome integrity and lead to cell death. Cells have evolved
a variety of processes to respond to DNA damage including damage repair and tolerance …

Highlights•DNA damage tolerance (DDT) modes are temporally separated within the cell-
cycle.•DNA bending and cohesion facilitate recombination-mediated DDT during …

When cells that are actively replicating DNA encounter sites of base damage or strand
breaks, replication might stall or arrest. In this situation, cells rely on DNA-damage-tolerance …

Preservation of genome integrity is an essential process for cell homeostasis. During the
course of life of a single cell, the genome is constantly damaged by endogenous and …

Mutations can be beneficial under conditions in which genetic diversity is advantageous,
such as somatic hypermutation and antibody generation, but they can also be lethal when …

DNA damage tolerance pathways, which include translesion DNA synthesis (TLS) and
template switching, are crucial for prevention of DNA replication arrest and maintenance of …

DNA-damage tolerance (DDT) is employed by eukaryotic cells to bypass replication-
blocking lesions induced by DNA-damaging agents. In budding yeast Saccharomyces …

The genomes of all living cells are under endogenous and exogenous attacks every day,
causing diverse genomic lesions. Most of the lesions can be timely repaired by multiple DNA …