Objective: Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), a key enzyme in collagen
synthesis, comprises two identical alpha subunits and two beta subunits. However, the …

Lung adenocarcinoma (LUAD) is a major pathological type of lung cancer. Understanding
the mechanism of LUAD at the molecular level is important for a clinical decision. In this …

The aims of this study were to investigate the expression of prolyl 4-hydroxylase subunit
alpha-1 (P4HA1) and its relationship with clinicopathological features in lung cancer (LC) …

Abstract Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is the core active catalytic portion of
prolyl 4-hydroxylase, and has contributed to tumorigenesis in several cancers. In this study …

Background: Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) provides the majority of the
catalytic site of the active P4H enzyme. Emerging evidence has revealed that P4HA1 …

Background Prolyl 4‐hydroxylase subunit alpha 1 (P4HA1) plays a critical role in modulating
the extracellular matrix and promoting tumor progression in various cancers. However, the …

Abstract Prolyl 4-hydroxylases (P4Hs) are a family of key modifying enzymes in collagen
synthesis. P4Hs have been confirmed to be closely associated with tumor occurrence and …

Lung cancer is the leading cause of cancer-related deaths globally and is histologically
defined as either small cell lung cancer (SCLC) or non-small cell lung cancer (NSCLC), with …

Background: Cervical cancer is one of the most common gynaecological malignancies.
Emerging studies have documented that prolyl-4-hydroxylase α subunit 2 (P4HA2) is …

Aim: We aimed to evaluate the diagnostic and prognostic values of P4HAs in breast cancer
(BC) patients. Materials & methods: Kaplan–Meier plotter was used to evaluate the …