Magneto-mechanical stimulation modulates osteocyte fate via the ECM-integrin-CSK axis and wnt pathway

B Zhang, X Li, X Zhou, CG Lou, S Wang, H Lv, G Zhang… - Iscience, 2023 - cell.com
Osteocytes are the mechano-sensors of bones. Large gradient high-static magnetic fields
(LG-HMFs) produce stable, high-precision, and non-attenuation mechanical forces. We …

Pulsed electromagnetic fields stimulation affects osteoclast formation by modulation of osteoprotegerin, RANK ligand and macrophage colony-stimulating factor

K Chang, WHS Chang, S Huang, S Huang… - Journal of Orthopaedic …, 2005 - Elsevier
Electromagnetic stimulation has been documented to treat recalcitrant problems of
musculoskeletal system. Yet, the underlying mechanisms are not completely understood. In …

Magnesium modulates the expression levels of calcification-associated factors to inhibit calcification in a time-dependent manner

J Xu, Y Bai, J Jin, J Zhang… - Experimental and …, 2015 - spandidos-publications.com
Vascular calcification, a common complication in patients with chronic kidney disease,
involves a variety of mechanisms associated with the regulation of calcification‑associated …

Bone morphogenetic protein-2 signaling in the osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields

F Martini, A Pellati, E Mazzoni, S Salati… - International Journal of …, 2020 - mdpi.com
Pulsed electromagnetic fields (PEMFs) are clinically used with beneficial effects in the
treatment of bone fracture healing. This is due to PEMF ability to favor the osteogenic …

Magnetically induced electrostimulation of human osteoblasts results in enhanced cell viability and osteogenic differentiation

B Hiemer, J Ziebart… - International …, 2016 - spandidos-publications.com
The application of electromagnetic fields to support the bone-healing processes is a
therapeutic approach for patients with musculoskeletal disorders. The ASNIS-III s-series …

[PDF][PDF] The effects of electromagnetic field on distraction osteogenesis

CC Kesemenli, M Subasi, H Kaya, C Sert… - Yonsei Medical …, 2003 - synapse.koreamed.org
The effects of electromagnetic field on distraction osteogenesis and new bony tissue were
investigated. Twenty-five New Zealand rabbits were divided into an experimental (12 …

MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1

G Xiao, D Jiang, P Thomas, MD Benson, K Guan… - Journal of Biological …, 2000 - ASBMB
The bone-specific transcription factor, Cbfa1, regulates expression of the osteocalcin (OCN)
gene and is essential for bone formation. However, little is known about the mechanisms …

Tensile stress induces bone morphogenetic protein 4 in preosteoblastic and fibroblastic cells, which later differentiate into osteoblasts leading to osteogenesis in the …

M Ikegame, O Ishibashi, T Yoshizawa… - Journal of Bone and …, 2001 - academic.oup.com
Mechanical stress is an important factor controlling bone remodeling, which maintains
proper bone morphology and functions. However, the mechanism by which mechanical …

Bone Morphogenic Protein--mRNA upregulation after exposure to low frequency electric field

M Hinsenkamp, JF Collard - International orthopaedics, 2011 - Springer
Purpose For many years, our laboratory has been investigating different biological
substrates for the effects of electromagnetic stimulation proposed in orthopaedic treatments …

Nitric oxide mediates the effects of pulsed electromagnetic field stimulation on the osteoblast proliferation and differentiation

P Diniz, K Soejima, G Ito - Nitric Oxide, 2002 - Elsevier
The purpose of this research was to investigate whether the effects of pulsed
electromagnetic field (PEMF) stimulation on the osteoblast proliferation and differentiation …