Publisher Summary Cell growth and differentiation are fundamental in bone development,
and as such they act as master regulators of bone development and remodeling. In space …

Mechanical stress is an important factor in bone homeostasis, which is maintained by a
balance between bone resorption by osteoclasts and bone formation by osteoblasts …

Signaling involved in osteoblastic cell differentiation remains largely unknown. This study
further investigates mechanisms involved in BMP‐2‐induced osteoblastic cell differentiation …

Once thought to provide only structural support to tissues by acting as a scaffold to which
cells bind, it is now widely recognized that the extracellular matrix (ECM) provides instructive …

Bone marrow cells obtained from rat femora were subjected to primary culture with 15% fetal
bovine serum in the presence of [TeX:] 10^{-8} M dexamethasone, and following trypsin …

The movements of life at every level from organs, tissues, cells to sub‐cells, are all
conducted in certain physical environments. In the human body, skeletal tissue among all …

The compliance of the extracellular matrix (ECM) regulates osteogenic differentiation by
modulating extracellular signal‐regulated kinase (ERK) activity. However, the molecular …

Exposure of osteosarcoma cell lines to chronic intermittent strain increases the activity of
mechano-sensitive cation (SA-cat) channels. The impact of mechano-transduction on …

Microgravity (MG) results in a reduction in bone formation. Bone formation involves
osteogenic differentiation from mesenchymal stem cells (hMSCs) in bone marrow. We …

We report the effects of pulsed electromagnetic fields (PEMFs) on the responsiveness of
osteoclasts to cellular, hormonal, and ionic signals. Osteoclasts isolated from neonatal rat …