In vivo functional genomics of Pseudomonas aeruginosa for high‐throughput screening of new virulence factors and antibacterial targets

E Potvin, DE Lehoux, I Kukavica‐Ibrulj… - Environmental …, 2003 - Wiley Online Library
Pseudomonas aeruginosa is a model for studying opportunistic pathogens that are highly
resistant to most classes of antibiotics and cause chronic pulmonary infections. We have …

Intrinsic and Environmental Mutagenesis Drive Diversification and Persistence of Pseudomonas aeruginosa in Chronic Lung Infections

A Rodríguez-Rojas, A Oliver… - Journal of Infectious …, 2012 - academic.oup.com
Pseudomonas aeruginosa is a versatile opportunistic pathogen causing a wide variety of
hospital-acquired acute infections in immunocompromised patients as well as chronic …

Pseudomonas aeruginosa : new insights into pathogenesis and host defenses

SL Gellatly, REW Hancock - Pathogens and disease, 2013 - academic.oup.com
Pseudomonas aeruginosa is a metabolically versatile bacterium that can cause a wide
range of severe opportunistic infections in patients with serious underlying medical …

Extensive Genomic Plasticity in Pseudomonas aeruginosa Revealed by Identification and Distribution Studies of Novel Genes among Clinical Isolates

K Shen, S Sayeed, P Antalis, J Gladitz… - Infection and …, 2006 - Am Soc Microbiol
The distributed genome hypothesis (DGH) states that each strain within a bacterial species
receives a unique distribution of genes from a population-based supragenome that is many …

[HTML][HTML] Positive Signature-Tagged Mutagenesis in Pseudomonas aeruginosa: Tracking Patho-Adaptive Mutations Promoting Airways Chronic Infection

I Bianconi, A Milani, C Cigana, M Paroni… - PLoS …, 2011 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa can establish life-long chronic
infections in the airways of cystic fibrosis (CF) patients. Persistent lifestyle is established with …

[HTML][HTML] Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis

JA Bartell, AS Blazier, P Yen, JC Thøgersen… - Nature …, 2017 - nature.com
Virulence-linked pathways in opportunistic pathogens are putative therapeutic targets that
may be associated with less potential for resistance than targets in growth-essential …

Integrated whole‐genome screening for Pseudomonas aeruginosa virulence genes using multiple disease models reveals that pathogenicity is host specific

JF Dubern, C Cigana, M De Simone… - Environmental …, 2015 - Wiley Online Library
P seudomonas aeruginosa is a multi‐host opportunistic pathogen causing a wide range of
diseases because of the armoury of virulence factors it produces, and it is difficult to …

Targeting mechanisms of Pseudomonas aeruginosa pathogenesis

E Kipnis, T Sawa, J Wiener-Kronish - Medecine et maladies infectieuses, 2006 - Elsevier
Pseudomonas aeruginosa is an opportunistic pathogen responsible for ventilator-acquired
pneumonia, acute lower respiratory tract infections in immunocompromised patients and …

[HTML][HTML] What It Takes to Be a Pseudomonas aeruginosa? The Core Genome of the Opportunistic Pathogen Updated

B Valot, C Guyeux, JY Rolland, K Mazouzi, X Bertrand… - PloS one, 2015 - journals.plos.org
Pseudomonas aeruginosa is an opportunistic bacterial pathogen able to thrive in highly
diverse ecological niches and to infect compromised patients. Its genome exhibits a mosaic …

Elucidating the molecular mechanisms of bacterial virulence using non‐mammalian hosts

S Mahajan‐Miklos, LG Rahme… - Molecular …, 2000 - Wiley Online Library
Several strains of the human opportunistic pathogen Pseudomonas aeruginosa infect
plants, nematodes and insects. Our laboratory has developed a multihost pathogenesis …