IN THE UNITED STATES, HEART FAILURE (HF) AFFECTS more than 5 million individuals,
accounts for nearly $40 billion in annual health care expenditures, 1 is associated with …

Heart failure (HF) is the quintessential cardiovascular syndrome of aging that results from
age-related cardiovascular conditions and age-associated changes in cardiovascular …

Thecurrentmanagementofpatientswithchron… failure depends on the noninvasive
measurement of left ventricular ejection fraction (LVEF). In patients with an LVEF of 40% or …

Although aging does not itself cause heart failure (HF), it does lower the threshold for
manifestation of the disease. As the populations of most developed countries continue to …

In this issue of the Journal, Ather et al.(1) report on the impact of noncardiac comorbidities
on outcomes in patients with heart failure (HF) with preserved ejection fraction (HFpEF) …

Heart failure (HF) is a complex clinical syndrome resulting from structural or functional
cardiac disorders. In the developed world, HF is primarily a disorder of the elderly. It is one …

One important factor that has contributed to our thinking about heart failure in patients with
normal or preserved ejection fraction (HFpEF) has been the perception that mortality in this …

Heart failure (HF) with preserved left ventricular (LV) ejection fraction (HFpEF) is uncommon
in younger persons, but highly prevalent in older adults, particularly women over age 80 …

Sixty years ago, Folse and Braunwald1 reported in this very journal a radioisotope
technique to determine the fraction of left ventricular (LV) end-diastolic volume ejected …

Importance Despite the importance of age, sex, and race/ethnicity representativeness in
clinical trials, limited data exist regarding the enrollment trends of these groups in …