Cancer causes significant morbidity and mortality worldwide, and is the area most targeted
in precision medicine. Recent development of high-throughput methods enables detailed …

A founding premise of the human genome project was that knowledge of the spectrum of
abnormalities that comprise cancers and other human diseases would lead to improved …

The acceleration of large-scale sequencing and the progress in high-throughput
computational analyses, defined as omics, was a hallmark for the comprehension of the …

The genomics era has yielded great advances in the understanding of cancer biology. At the
same time, the immense complexity of the cancer genome has been revealed, as well as a …

High-throughput methods to investigate tumour omic landscapes have quickly catapulted
cancer specialists into the precision oncology era. The singular lesson of precision oncology …

Studies describing the expression patterns and biomarkers for the tumoral process increase
in number every year. The availability of new datasets, although essential, also creates a …

The manifestations of cancerous phenotypes necessitate alterations at different levels of
information-flow from genome to proteome. The molecular alterations at different information …

Recent advances in omics technologies have led to unprecedented efforts characterizing
the molecular changes that underlie the development and progression of a wide array of …

The overall goal of translational oncology is to identify molecular alterations indicative of
cancer or of responsiveness to specific therapeutic regimens. While next-generation …

The number of druggable tumor-specific molecular aberrations has grown substantially in
the past decade, with a significant survival benefit obtained from biomarker matching …