Background: Cigarette smoking is the main cause of preventable death in developed
countries. While the direct positive behavioral reinforcing effect of nicotine has historically …

Given the large availability of nicotinic acetylcholine receptors (nAChRs) throughout the
brain, and the wide range of neurotransmitter systems affected (norepinephrine, serotonin …

Substantial evidence demonstrates both nicotine's addiction liability and its cognition-
enhancing effects. However, the neurobiological mechanisms underlying nicotine's impact …

Understanding nicotine's neurobiological and cognitive mechanisms may help explain both
its addictive properties and potential therapeutic applications. As such, functional MRI was …

While most cigarette smokers endorse a desire to quit smoking, only 14–49% will achieve
abstinence after 6 months or more of treatment. A greater understanding of the effects of …

Nicotine enhances cognitive performance in humans and laboratory animals. The
immediate positive actions of nicotine on learning, memory and attention are well …

Cigarette smoking rates in the American population are approximately 23%, whereas rates
of smoking in clinical and population studies of individuals with neuropsychiatric disorders …

While most cigarette smokers endorse a desire to quit smoking, only about 14% to 49% will
achieve abstinence after 6 months or more of treatment. A greater understanding of the …

Context Understanding the mechanisms underlying nicotine addiction to develop more
effective treatment is a public health priority. Research consistently shows that nicotine …

To elucidate the neural correlates of cognitive effects of nicotine, we examined behavioral
performance and blood oxygenation level-dependent regional brain activity, using functional …