It has previously been shown that the reinforcing and dependence-producing properties of
nicotine depend to a great extent on activation of nicotinic receptors within the ventral …

Nicotine stimulates brain reward circuitries, most prominently the mesocorticolimbic
dopamine system, and this action plays a critical in establishing and maintaining the tobacco …

BACKGROUND: Developing the means to identify smokers at high risk for relapse could
advance relapse prevention therapy. We hypothesized that functional magnetic resonance …

This functional magnetic resonance imaging study investigates the effects of nicotine in a
cued target detection task when changing cue reliability. Fifteen non-smoking volunteers …

Nicotine is the principal addictive component that drives continued tobacco use despite
users' knowledge of the harmful consequences. The initiation of addiction involves the …

Tobacco smoking continues to be a major global health hazard despite significant public
awareness of its harmful consequences. Although several treatment options are currently …

In addition to reward-and craving-related processes, habitual mechanisms play an important
role in addiction. While the dorsal striatum has been proposed to code for the motivational …

Nicotine sustains addictive tobacco use, which in turn causes much premature disability and
death. The essence of drug addiction is loss of control of drug use. Molecular biology studies …

Objective Allelic variation in the α5 nicotinic acetylcholine receptor (nAChR) subunit gene,
CHRNA5, increases vulnerability to tobacco addiction. Here, we investigated the role of α5 …

The identification of the molecular mechanisms involved in nicotine addiction and its
cognitive consequences is a worldwide priority for public health. Novel in vivo paradigms …