More than 70% of adolescents report to have smoked a cigarette at least once. At the
adolescent stage the brain has not completed its maturation. The prefrontal cortex (PFC), the …

Pre-adolescence and adolescence are developmental periods associated with increased
vulnerability for tobacco addiction, and exposure to tobacco during these periods may lead …

The prefrontal cortex (PFC) is responsible for integrating cortical and subcortical inputs to
execute essential cognitive functions such as attention, working memory planning and …

BACKGROUND:: Nicotine improves cognition in humans and animal models of
neuropsychiatric disorders. Here, we sought to establish whether selective stimulation of the …

Cigarette smoking is the leading cause of preventable deaths worldwide, and nicotine, the
primary psychoactive constituent in tobacco, drives sustained use. The behavioral actions of …

Nicotine addiction is initiated by its binding to high-affinity nicotinic receptors in brain
composed primarily of α4 and β2 subunits. For nicotinic receptors expressed in vivo or …

Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …