Over the last decade, we have witnessed an explosion of information on genetic factors
underlying common human diseases and disorders. This 'human genomics 'information …

The brave new world envisioned by proponents of personalized medicine has attracted
considerable interest and investment during the past decade or so. The excitement is …

Although it is recognized that many common complex diseases are a result of multiple
genetic and environmental risk factors, studies of gene‐environment interaction remain a …

Trevor K. Archer Paul A. Wade the cell cycle, in response to biologic signaling systems, and
with environmental changes. Deciphering how the epigenome responds to environmental …

A growing body of evidence has drawn the attention of the scientific community by indicating
the potential vulnerability to environmental changes of epigenetic mechanisms that control …

The lack of knowledge about the earliest events in disease development is due to the multi-
factorial nature of disease risk. This information gap is the consequence of the lack of …

In the spring of 1998 my co-editor, colleague and friend, Randy Jirtle, approached me at a
scientific meeting in San Diego, CA to discuss something that clearly had him excited …

Emerging research demonstrates that diet, pollution, and other environmental triggers can
alter both the function and expression of human genes and lead to a heightened disease …

In recent years, research on how the human environment and lifestyle influence gene
expression has generated considerable scientific and public interest. Articles in prominent …

Over 75% of direct medical costs in the US are for chronic conditions (Hoffman et al., 1996),
a situation that we can reasonably presume to increase in the future. Despite the need for …