In type 1 diabetes (T1D) β cell mass is markedly reduced by autoimmunity. Type 2 diabetes
(T2D) results from inadequate β cell mass and function that can no longer compensate for …

Type 2 diabetes is characterized by insulin resistance and a progressive loss of β‐cell
function induced by a combination of both β‐cell loss and impaired insulin secretion from …

Regulation of blood glucose concentrations requires an adequate number of β‐cells that
respond appropriately to blood glucose levels. β‐Cell mass cannot yet be measured in …

Although it is well established that type 2 diabetes (T2D) is generally due to the progressive
loss of β-cell insulin secretion against a background of insulin resistance, the actual …

Studies of long-standing type 2 diabetes (T2D) report a deficit in β-cell mass due to
increased apoptosis, whereas neogenesis and replication are unaffected. It is unclear …

Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

In nondiabetic subjects, insulin secretion is sufficiently increased as a compensatory
adaptation to insulin resistance whereas in subjects with type 2 diabetes, the adaptation is …

Type 1 and type 2 diabetes have often been presented as disease forms that profoundly
differ in the presence and pathogenic significance of a reduced β‐cell mass. We review …

Type 2 diabetes is increasingly viewed as a disease of insulin deficiency due not only to
intrinsic pancreatic β-cell dysfunction but also to reduction of β-cell mass. It is likely that, in …

OBJECTIVE—β-Cell regeneration is a fundamental but elusive goal for type 1 diabetes
research. Our objective is to review newer human and animal studies of β-cell destruction …