[HTML][HTML] The dark side of melanin secretion in cutaneous melanoma aggressiveness
Skin cancers are among the most common cancers worldwide and are increasingly
prevalent. Cutaneous melanoma (CM) is characterized by the malignant transformation of …
prevalent. Cutaneous melanoma (CM) is characterized by the malignant transformation of …
[HTML][HTML] Melanoma, melanin, and melanogenesis: The Yin and Yang relationship
Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet
radiation and other environmental stressors. It is produced by the enzymatic transformation …
radiation and other environmental stressors. It is produced by the enzymatic transformation …
[HTML][HTML] Melanogenesis and the targeted therapy of melanoma
C Li, L Kuai, R Cui, X Miao - Biomolecules, 2022 - mdpi.com
Pigment production is a unique character of melanocytes. Numerous factors are linked with
melanin production, including genetics, ultraviolet radiation (UVR) and inflammation …
melanin production, including genetics, ultraviolet radiation (UVR) and inflammation …
Oxidative stress in melanogenesis and melanoma development
K Kamiński, U Kazimierczak, T Kolenda - Contemporary Oncology …, 2022 - termedia.pl
Melanoma is the most aggressive skin cancer, with a growing number of incidents
worldwide and with no effective cure in a metastatic stage so far. There are several …
worldwide and with no effective cure in a metastatic stage so far. There are several …
[HTML][HTML] Role of melanin chemiexcitation in melanoma progression and drug resistance
S Premi - Frontiers in Oncology, 2020 - frontiersin.org
Melanoma is the deadliest type of skin cancer. Human melanomas often show hyperactivity
of nitric oxide synthase (NOS) and NADPH oxidase (NOX), which, respectively, generate …
of nitric oxide synthase (NOS) and NADPH oxidase (NOX), which, respectively, generate …
[HTML][HTML] Exploring the complex and multifaceted interplay between melanoma cells and the tumor microenvironment
M Kuras - International Journal of Molecular Sciences, 2023 - mdpi.com
Malignant melanoma is a very aggressive skin cancer, characterized by a heterogeneous
nature and high metastatic potential. The incidence of melanoma is continuously increasing …
nature and high metastatic potential. The incidence of melanoma is continuously increasing …
[HTML][HTML] Loss of 'epidermal melanin unit'integrity in human skin during melanoma-genesis
Cutaneous melanoma can be a most challenging neoplasm of high lethality, in part due to
its extreme heterogeneity and characteristic aggressive and invasive nature. Indeed, its …
its extreme heterogeneity and characteristic aggressive and invasive nature. Indeed, its …
The melanoma revolution: from UV carcinogenesis to a new era in therapeutics
JA Lo, DE Fisher - Science, 2014 - science.org
Melanoma, the deadliest form of skin cancer, is an aggressive disease that is rising in
incidence. Although melanoma is a historically treatment-resistant malignancy, in recent …
incidence. Although melanoma is a historically treatment-resistant malignancy, in recent …
[HTML][HTML] Melanoma metastasis: What role does melanin play?
A Saud, SR Sagineedu, HS Ng… - Oncology …, 2022 - spandidos-publications.com
Melanoma is an extremely aggressive form of skin cancer that can spread to the lungs,
brain, and liver, among other vital organs. Melanoma cells, unlike any other cancer cells …
brain, and liver, among other vital organs. Melanoma cells, unlike any other cancer cells …
Emerging molecular targets in melanoma invasion and metastasis
JL Orgaz, V Sanz‐Moreno - Pigment cell & melanoma research, 2013 - Wiley Online Library
Metastatic cutaneous melanoma accounts for the majority of skin cancer deaths due to its
aggressiveness and high resistance to current therapies. To efficiently metastasize, invasive …
aggressiveness and high resistance to current therapies. To efficiently metastasize, invasive …