Melanoma arises through the accrual of mutations in genes critical for proliferation and
survival. Although melanoma had been traditionally conceptualized as a cell-autonomous …

Cutaneous melanoma (CM) encompasses a group of pigmented tumors that arise from skin
melanocytes. Melanocytes are neural crest-derived cells that commonly migrate to the skin …

Melanoma develops as a result of several genetic alterations, with UV radiation often acting
as a mutagenic risk factor. Deep knowledge of the molecular signaling pathways of different …

Malignant melanoma is a very representative disease in terms of tumor progression
processes. During its evolution, a series of events takes place; among these, the cells''out-of …

Melanoma develops from a series of architectural and phenotypically distinct stages and
becomes progressively aggressive culminating in metastasis. Over the years, considerable …

Recent insights into the genetic and somatic aberrations have initiated a new era of rapidly
evolving targeted and immune-based treatments for melanoma. After decades of …

Unwanted growth breeds response–in the garden as well as in the tumor microenvironment.
Innate immune cells mediate the earliest responses against melanoma or its precursors …

Melanoma, a highly aggressive skin cancer, is characterized by rapid progression and high
mortality. Recent advances in molecular pathogenesis have shed light on genetic and …

Recent advances in mouse genetics have identified molecular changes that are critical for
melanocyte maturation and differentiation. This review briefly summarizes the current …

The incidence of skin cancers, both nonmelanoma and melanoma, is increasing in the
United States. The ultraviolet radiation, mainly from sun, is considered the major cause for …