Lentivirus-derived vectors are among the most promising viral vectors for gene therapy
currently available, but their use in clinical practice is limited by the associated risk of …

Nonintegrating lentiviral (NIL) vectors were produced from HIV-1-based lentiviral vectors by
introducing combinations of mutations made to disable the integrase protein itself and to …

Lentiviral vectors (LVs) offer the advantages of a large packaging capacity, broad cell
tropism or specific cell-type targeting through pseudotyping, and long-term expression from …

We describe the construction of a safe, replication-defective and efficient lentiviral vector
suitable for in vivo gene delivery. The reverse transcription of the vector was found to be a …

Nonintegrating lentiviral vectors present a means of reducing the risk of insertional
mutagenesis in nondividing cells and enabling short-term expression of potentially …

Lentiviral vectors are among the most efficient gene transfer tools for dividing and non-
dividing cells. However, insertional mutagenesis has been observed in clinical trials with …

Gene correction aims at repairing a defective gene directly in the cellular genome, which
warrants tissue-specific and sustained expression of the repaired gene through its …

High levels of circular viral extrachromosomal DNA (E-DNA) are normally produced after
infection with integration-competent and-incompetent lentiviruses. Although E-DNA has …

The circumstances under which unintegrated lentivirus DNA can persist and be a functional
template for transcription and protein expression are not clear. We constructed and validated …

Vectors based on lentiviruses have become potent tools for efficient gene transfer to multiple
cell types both in vitro and in vivo. In part this is attributable to the stability of transduction …