[HTML][HTML] Experimental design, formulation and in vivo evaluation of a novel topical in situ gel system to treat ocular infections

AB Nair, J Shah, S Jacob, BE Al-Dhubiab… - PloS one, 2021 - journals.plos.org
In situ gels have been extensively explored as ocular drug delivery system to enhance
bioavailability and efficacy. The objective of present study was to design, formulate and …

Levofloxacin hemihydrate ocular semi-sponges for topical treatment of bacterial conjunctivitis: Formulation and in-vitro/in-vivo characterization

O Saher, DM Ghorab, NM Mursi - Journal of Drug Delivery Science and …, 2016 - Elsevier
This study aimed to formulate and evaluate lyophilized, long acting, levofloxacin
hemihydrate ocular semi-sponges that would fit cul-de-sac shape for bacterial conjunctivitis …

Development of besifloxacin HCl loaded nanofibrous ocular inserts for the treatment of bacterial keratitis: In vitro, ex vivo and in vivo evaluation

HK Polat, SB Pehlivan, C Özkul, S Çalamak… - International journal of …, 2020 - Elsevier
Novel drug delivery systems have emerged to treat bacterial keratitis, an acute infection of
the cornea. In this study, besifloxacin HCl loaded insert formulations were designed and …

Development and optimization of hot-melt extruded moxifloxacin hydrochloride inserts, for ocular applications, using the design of experiments

R Thakkar, N Komanduri, N Dudhipala… - International journal of …, 2021 - Elsevier
The current study sought to formulate sustained-release hot-melt extruded (HME) ocular
inserts of moxifloxacin hydrochloride (MOX; MOX-HME) for the treatment of bacterial …

Design and evaluation of polymeric ocular drug delivery system

AP Gorle, SG Gattani - Chemical and Pharmaceutical Bulletin, 2009 - jstage.jst.go.jp
The objective of the present study was to prepare ocular inserts of Gatifloxacin. The inserts
were fabricated by solvent casting technique, with an aim by achieving once a day …

Comparative studies for ciprofloxacin hydrochloride pre-formed gels and thermally triggered (in situ) gels: in vitro and in vivo appraisal using a bacterial keratitis …

H Abdelkader, HF Mansour - Pharmaceutical Development and …, 2015 - Taylor & Francis
This article reports on comparative in vitro characterization and in vivo evaluation of pre-
formed cellulose-based gels, methylcellulose (MC) and carboxymethylcellulose sodium …

[HTML][HTML] Multicomposite ultrathin capsules for sustained ocular delivery of ciprofloxacin hydrochloride

D Bhadra, G Gupta, S Bhadra… - J. Pharm. Pharm …, 2004 - ualberta.ca
PURPOSE: The present work is intended to develop a sustained bioadhesive drug delivery
system for delivery of Ciprofloxacin Hydrochloride in Cul-de-Sac for sustained and effective …

Development and evaluation of ocular drug delivery system

AP Gorle, SG Gattani - Pharmaceutical development and …, 2010 - Taylor & Francis
The eye presents unique opportunities and challenges when it comes to the delivery of
pharmaceuticals. In the present study, ocular inserts of levofloxacin were prepared using …

[PDF][PDF] Ophthalmic in-situ sustained gel of ciprofloxacin, preparation and evaluation study

FY Al-Bazzaz, M Al-Kotaji - Int J App Pharm, 2018 - academia.edu
Objective: This work aims to formulate and evaluate an ophthalmic in-situ gel of ciprofloxacin
hydrochloride (HCl) using poloxamer 407 (P407) as a gelling agent and hydroxypropyl …

[HTML][HTML] An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retention

H Gupta, M Aqil, RK Khar, A Ali… - Journal of Pharmacy …, 2015 - journals.lww.com
Objective: The objective of our work was to formulate an ocular delivery system of
levofloxacin, based on the concept of ion (sodium alginate) and pH (chitosan) activated in …