99mTc-EC20 is a folate receptor (FR)–targeted imaging agent consisting of the vitamin
folate conjugated to 99mTc. FR is expressed on a variety of epithelial cancers, with …

Our group previously reported on the synthesis and characterization of a novel 99mTc-
based folate-peptide chelator called EC20. This agent was found to bind folate receptor (FR) …

Conventional cancer treatment modalities have several limitations including lack of sufficient
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …

Folate receptor (FR) can be used as a therapeutic target because of its expression on
different epithelial cancers, such as ovarian, non–small cell lung, endometrial, and breast …

Folate receptors are up-regulated on a variety of human cancers, including cancers of the
breast, ovaries, endometrium, lungs, kidneys, colon, brain, and myeloid cells of …

99mTc-technetium (99mTc) and 188Re-rhenium (188Re) represent an interesting pair of
radionuclides for diagnosis and therapy. The aim of this study was to synthesize and …

Targeting the folate receptor (α-FR) with radiolabeled folates for the noninvasive diagnosis
and therapy of α-FR–overexpressing neoplastic tissue is of great interest. However, the …

The folate receptor (FR) has been established as a promising target for imaging and therapy
of cancer (FR-α), inflammation, and autoimmune diseases (FR-β). Several folate based PET …

Purpose The folate receptor (FR) is a valuable tumour marker, since it is frequently
overexpressed on various cancer types. The purpose of the present study was to pre …

Over-expression of folate receptor alpha on cancer cells has been frequently exploited for
delivery of folate-targeted imaging and therapeutic agents to tumors. Because limited …