Insulin signaling defects could lead to insulin resistance in insulin target organs: typically, in
the muscler, liver, and adipose tissue. We have observed that insulin accelerated diabetic …

Background Wound healing is impaired in diabetes mellitus, but the mechanisms involved in
this process are virtually unknown. Proteins belonging to the insulin signaling pathway …

Inflammation, the initiating stage of wound healing, is characterized by increased
endothelial permeability, infiltration of inflammatory cells, and secretion of numerous growth …

Background. Diabetes is a condition known even in its early stages to impair the normal
course of wound healing, thus leading to chronic wounds. The role of insulin in the …

Besides regulating glucose levels, insulin has been reported to participate actively in many
other functions, including modulating inflammatory reactions. In this study we investigated …

Abstract Diabetic foot ulcers affect 15–20% of all diabetic patients and remain an important
challenge since the available therapies have limited efficacy and some of the novel …

The healing time of burn wounds depends on surface area and depth of the burn and
associated comorbidities. Diabetes mellitus (DM) causes delays in the healing process by …

The healing process is complex in diabetic wounds, and the healing mechanism of burn
wounds is different from that of incisional or excisional wounds. Data from our previous study …

Wound-healing disorders are major complications of diabetes mellitus. Here, we
investigated insulin-mediated signaling in nonwounded skin and in cutaneous tissue …

Diabetes mellitus is associated with impaired wound healing. The topical use of insulin is a
promising therapy because it may favor all phases of the wound healing process. This study …