In this study we evaluate the antitumour activity, the cell cycle arrest and apoptotic properties
of novel lipophilic benzene-fused seven-membered 5-fluorouracil (5-FU) analogs in …

Attention is increasingly being focussed on the cell cycle and apoptosis as potential targets
for therapeutic intervention in cancer. We prepared a series of bioisosteric benzannelated …

On the basis of the increase in lipophilicity, novel benzannelated six-and seven-membered
derivatives have been synthesized, starting from 2-hydroxybenzyl alcohols, 2 …

Advance in the knowledge of molecular biology has thrown light on many aspects of
apoptosis regulation mechanisms. This has allowed a change in anti-cancer therapy trends …

Triple negative breast cancer (TNBC) is a breast cancer subtype characterized by the
absence of estrogen receptor, progesterone receptor and human epidermal growth factor …

Breast cancer is the most common malignancy and the leading cause of cancer-related
death in women worldwide. High toxicity of used chemotherapeutics and resistance of …

We have focused our attention on the development of a novel form of a tegafur-based [FT; a
prodrug of 5-fluorouracil (5-FU)] antitumor agent. We have used two biochemical and …

The synthesis of new 3-cyano-2-substituted pyridines bearing various pharmacophores and
functionalities at position 2 is described. The synthesized compounds were evaluated for …

Treatment with 5-fluorouracil and its derivatives causes DNA double strand breaks in the S
phase, and the subsequent cell death. A 5-Fluorouracil derivative (UFT), that is converted to …

A series of ursolic acid ((1S, 2R, 4aS, 6aR, 6aS, 6bR, 8aR, 10S, 12aR, 14bS)‐10‐hydroxy‐
1, 2, 6a, 6b, 9, 9, 12a‐heptamethyl‐2, 3, 4, 5, 6, 6a, 7, 8, 8a, 10, 11, 12, 13, 14b …