Atypical hemolytic uremic syndrome: a syndrome in need of clarity

BE Berger - Clinical Kidney Journal, 2019 - academic.oup.com
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA)
originally understood to be limited to renal and hematopoietic involvement. Whereas …

[HTML][HTML] An update for atypical haemolytic uraemic syndrome: diagnosis and treatment. A consensus document

JM Campistol, M Arias, G Ariceta, M Blasco… - Nefrología (English …, 2015 - Elsevier
Haemolytic uraemic syndrome (HUS) is a clinical entity defined as the triad of nonimmune
haemolytic anaemia, thrombocytopenia, and acute renal failure, in which the underlying …

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

K Smith-Jackson, Y Yang, H Denton… - The Journal of …, 2019 - Am Soc Clin Investig
Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-
function mutations in complement-regulating proteins or gain-of-function mutations in …

Tailored eculizumab therapy in the management of complement factor H–mediated atypical hemolytic uremic syndrome in an adult kidney transplant recipient: a case …

L Xie, CM Nester, AI Reed, Y Zhang, RJ Smith… - Transplantation …, 2012 - Elsevier
Atypical hemolytic uremic syndrome (aHUS) is characterized by thrombocytopenia,
microangiopathic hemolytic anemia, and acute kidney injury (AKI) which frequently …

Atypical hemolytic uremic syndrome associated with mutations in complement regulator genes

M Le Quintrec, L Roumenina, M Noris… - … in thrombosis and …, 2010 - thieme-connect.com
In the last 10 years the knowledge of the pathophysiology of atypical hemolytic uremic
syndrome (aHUS) has substantially increased. Nevertheless, aHUS remains a severe …

Eculizumab as first-line therapy for atypical hemolytic uremic syndrome

M Christmann, M Hansen, C Bergmann… - …, 2014 - publications.aap.org
Atypical hemolytic uremic syndrome (aHUS) is a genetic, life-threatening, chronic disease
that can affect patients of all ages. aHUS is caused by uncontrolled complement activation …

Can eculizumab be discontinued in aHUS?: case report and review of the literature

T Sahutoglu, T Basturk, T Sakaci, Y Koc, E Ahbap… - Medicine, 2016 - journals.lww.com
Background: The management of atypical hemolytic uremic syndrome (aHUS) has evolved
into better control of thrombotic microangiopathy (TMA) and recovery of renal functions since …

Atypical hemolytic uremic syndrome

C Loirat, V Frémeaux-Bacchi - Orphanet journal of rare diseases, 2011 - Springer
Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical hemolytic anemia,
thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shiga-toxin …

Eculizumab reduces complement activation, inflammation, endothelial damage, thrombosis, and renal injury markers in aHUS

R Cofiell, A Kukreja, K Bedard, Y Yan… - Blood, The Journal …, 2015 - ashpublications.org
Atypical hemolytic uremic syndrome (aHUS) is a genetic, life-threatening disease
characterized by uncontrolled complement activation, systemic thrombotic microangiopathy …

The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment

E Rondeau, M Scully, G Ariceta, T Barbour… - Kidney International, 2020 - Elsevier
Ravulizumab is a long-acting C5 inhibitor engineered from eculizumab with increased
elimination half-life, allowing an extended dosing interval from two to eight weeks. Here we …