[HTML][HTML] Optimal duration of treatment with eculizumab in atypical hemolytic uremic syndrome (aHUS)—a question to be addressed in a scientific way

G Ariceta - Pediatric Nephrology, 2019 - Springer
Atypical hemolytic uremic syndrome (aHUS) is an ultrarare disease caused, in most cases,
by dysregulation of the alternative complement (C′) pathway at the surface of the vascular …

Biomarkers of terminal complement activation confirm the diagnosis of aHUS and differentiate aHUS from TTP

SR Cataland, VM Holers, S Geyer… - Blood, The Journal of …, 2014 - ashpublications.org
Atypical hemolytic uremic syndrome (aHUS) is characterized by dysregulated complement
activity, the development of a thrombotic microangiopathy (TMA), and widespread end organ …

Safety and effectiveness of restrictive eculizumab treatment in atypical haemolytic uremic syndrome

KL Wijnsma, C Duineveld, EB Volokhina… - Nephrology Dialysis …, 2018 - academic.oup.com
Background Atypical haemolytic uremic syndrome (aHUS) is a rare but severe form of
thrombotic microangiopathy as a consequence of complement dysregulation. aHUS has a …

Hemolytic uremic syndrome: an example of insufficient complement regulation on self‐tissue

JP Atkinson, MK Liszewski, A Richards… - Annals of the New …, 2005 - Wiley Online Library
Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia,
thrombocytopenia, and acute renal failure. HUS is classified as either diarrhea associated …

[PDF][PDF] A new era in the diagnosis and treatment of atypical haemolytic uraemic syndrome

D Westra, JF Wetzels, EB Volokhina… - Neth J Med, 2012 - academia.edu
The haemolytic uraemic syndrome (HUS) is characterised by haemolytic anaemia,
thrombocytopenia and acute renal failure. The majority of cases are seen in childhood and …

[HTML][HTML] Secondary atypical hemolytic uremic syndromes in the era of complement blockade

M Praga, SR de Córdoba - Kidney International, 2019 - Elsevier
Le Clech et al. found rare variants in complement genes in only 5% of patients among a
large cohort of secondary hemolytic uremic syndrome cases. The absence of genetic …

[HTML][HTML] Atypical hemolytic-uremic syndrome: a case report and literature review

A Rafiq, H Tariq, N Abbas, R Shenoy - The American Journal of …, 2015 - ncbi.nlm.nih.gov
Objective: Rare disease Background: Atypical hemolytic uremic syndrome (aHUS) is a rare
disease characterized by hemolysis, thrombocytopenia, and renal dysfunction. It is a …

[PDF][PDF] Atypical hemolytic uremic syndrome (aHUS): making the diagnosis

J Laurence - Clin Adv Hematol Oncol, 2012 - hematologyandoncology.net
Atypical hemolytic uremic syndrome (aHUS) is a major thrombotic microangiopathy (TMA). A
TMA is recognized by the laboratory signs of microangiopathic hemolysis, as indicated by …

Plasmatherapy in atypical hemolytic uremic syndrome

C Loirat, A Garnier, AL Sellier-Leclerc… - … in thrombosis and …, 2010 - thieme-connect.com
Plasmatherapy has become empirically first-line treatment in atypical hemolytic uremic
syndrome (aHUS), although no prospective controlled trials have been conducted. Patients …

Eculizumab cessation in atypical hemolytic uremic syndrome

SA Merrill, ZD Brittingham, X Yuan… - Blood, The Journal …, 2017 - ashpublications.org
Atypical hemolytic uremic syndrome (aHUS) is a complementmediated thrombotic
microangiopathy (TMA) characterized by mechanical hemolysis, renal impairment …