Ni (II) specifically cleaves the C-terminal tail of the major variant of histone H2A and forms an oxidative damage-mediating complex with the cleaved-off octapeptide
W Bal, R Liang, J Lukszo, SH Lee… - Chemical Research …, 2000 - ACS Publications
The acetyl-TESHHK-amide peptide, modeling a part of the C-terminal “tail” of histone H2A,
was found previously by us to undergo at pH 7.4 a Ni (II)-assisted hydrolysis of the E− S …
was found previously by us to undergo at pH 7.4 a Ni (II)-assisted hydrolysis of the E− S …
The octapeptidic end of the C-terminal tail of histone H2A is cleaved off in cells exposed to carcinogenic nickel (II)
AA Karaczyn, W Bal, SL North, RM Bare… - Chemical research in …, 2003 - ACS Publications
We have demonstrated previously that Ni (II) binds to the C-terminal− TESHHKAKGK motif of
isolated bovine histone H2A. At physiological pH, the bound Ni (II) assists in hydrolysis of …
isolated bovine histone H2A. At physiological pH, the bound Ni (II) assists in hydrolysis of …
Stray Cu (II) may cause oxidative damage when coordinated to the-TESHHK-sequence derived from the C-terminal tail of histone H2A
M Mylonas, G Malandrinos, J Plakatouras… - Chemical Research …, 2001 - ACS Publications
CH3CO-Thr-Glu-Ser-His-His-Lys-NH2, a hexapeptide representing the 120− 125 sequence
of histone H2A, coordinates Cu (II) ions efficiently. Monomeric complexes are formed. In the …
of histone H2A, coordinates Cu (II) ions efficiently. Monomeric complexes are formed. In the …
Interactions of Nickel(II) with Histones: Interactions of Nickel(II) with CH3CO-Thr-Glu-Ser-His-His-Lys-NH2, a Peptide Modeling the Potential Metal Binding Site in …
W Bal, J Lukszo, K Bialkowski… - Chemical research in …, 1998 - ACS Publications
A combined pH-metric and spectroscopic (UV/vis, CD, NMR) study of the Ni (II) binding to
CH3CO-Thr-Glu-Ser-His-His-Lys-NH2 (AcTESHHKam), a blocked hexapeptide modeling a …
CH3CO-Thr-Glu-Ser-His-His-Lys-NH2 (AcTESHHKam), a blocked hexapeptide modeling a …
Truncation, deamidation, and oxidation of histone H2B in cells cultured with nickel (II)
AA Karaczyn, F Golebiowski… - Chemical research in …, 2005 - ACS Publications
Molecular mechanisms of nickel-induced carcinogenesis include interactions of Ni (II)
cations with histones. Previously, we demonstrated in vitro and in cells that Ni (II) cleaved off …
cations with histones. Previously, we demonstrated in vitro and in cells that Ni (II) cleaved off …
Interactions of nickel (II) with histones. Stability and solution structure of complexes with CH3CO-Cys-Ala-Ile-His-NH2, a putative metal binding sequence of histone H3
W Bal, J Lukszo, M Jezowska-Bojczuk… - Chemical research in …, 1995 - ACS Publications
Nickel (II) compounds are established human carcinogens, but the molecular mechanisms
underlying their activity are only partially known. One mechanism may include mediation by …
underlying their activity are only partially known. One mechanism may include mediation by …
Interactions of Nickel(II) with Histones: Enhancement of 2'-Deoxyguanosine Oxidation by Ni(II) Complexes with CH3CO-Cys-Ala-Ile-His-NH2, a Putative Metal …
W Bal, J Lukszo, KS Kasprzak - Chemical research in toxicology, 1996 - ACS Publications
Studies of 2 '-deoxyguanosine oxidation by hydrogen peroxide in the presence of CH3CO-
Cys-Ala-Ile-His-NH2 (CAIH) and/or NiCl2 have been carried out in 100 mM phosphate buffer …
Cys-Ala-Ile-His-NH2 (CAIH) and/or NiCl2 have been carried out in 100 mM phosphate buffer …
Ni(II)·Xaa-Xaa-His Induced DNA Cleavage: Deoxyribose Modification by a Common “Activated” Intermediate Derived from KHSO5, MMPP, or H2O2
Q Liang, DC Ananias, EC Long - Journal of the American …, 1998 - ACS Publications
Ni (II) chelated peptides of the form NH2-Xaa-Xaa-His-CONH2 (Ni (II)⊙ Xaa-Xaa-His)
mediate deoxyribose damage through C4 '− H abstraction of a targeted nucleotide when …
mediate deoxyribose damage through C4 '− H abstraction of a targeted nucleotide when …
Mediation of oxidative DNA damage by nickel (II) and copper (II) complexes with the N-terminal sequence of human protamine HP2
W Bal, J Lukszo, KS Kasprzak - Chemical research in toxicology, 1997 - ACS Publications
The potential of Ni (II) and Cu (II) complexes with Arg-Thr-His-Gly-Gln-Ser-His-Tyr-Arg-Arg-
Arg-His-Cys-Ser-Arg-amide (HP21-15), a peptide modeling the N-terminal amino acid …
Arg-His-Cys-Ser-Arg-amide (HP21-15), a peptide modeling the N-terminal amino acid …
Relevance of arginine residues in Cu (II)-induced DNA breakage and Proteinase K resistance of H1 histones
M Piscopo, M Trifuoggi, C Scarano, C Gori, A Giarra… - Scientific Reports, 2018 - nature.com
This work analyzes the involvement of arginines in copper/H2O2-induced DNA breakage.
Copper is a highly redox active metal which has been demonstrated to form compounds with …
Copper is a highly redox active metal which has been demonstrated to form compounds with …