Development and validation of an ELISA kit for the detection of ricin toxins from biological specimens and environmental samples

HY Chen, H Tran, LY Foo, TW Sew… - Analytical and bioanalytical …, 2014 - Springer
Ricin is a toxin that can be easily extracted from seeds of Ricinus communis plants. Ricin is
considered to be a major bio-threat as it can be freely and easily acquired in large …

Evaluation of ricinine, a ricin biomarker, from a non-lethal castor bean ingestion

EI Hamelin, RC Johnson, JD Osterloh… - Journal of analytical …, 2012 - academic.oup.com
A case is presented of the attempted suicide of a 58-year-old man using castor beans. The
patient came to the emergency room complaining of nausea, vomiting and diarrhea for nine …

[HTML][HTML] Detection of ricin activity and structure by using novel galactose-terminated magnetic bead extraction coupled with mass spectrometric detection

K Hoyt, JR Barr, SR Kalb - Analytical biochemistry, 2021 - Elsevier
Ricin is a toxic protein derived from the castor bean plant (Ricinus communis) and has
potential for bioterrorism or criminal use. Therefore, sensitive and rapid analytical methods …

Identification of ricin in crude and purified extracts from castor beans using on-target tryptic digestion and MALDI mass spectrometry

CS Brinkworth - Analytical chemistry, 2010 - ACS Publications
Ricin is a toxic protein produced in the seeds of the castor bean plant. The toxicity of the
protein and the ease in which it can be extracted from the seeds makes it a potential …

Detection of ricin in complex samples by immunocapture and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

E Duriez, F Fenaille, JC Tabet… - Journal of Proteome …, 2008 - ACS Publications
Ricin, the toxin component of Ricinus communis is considered as a potential chemical
weapon. Several complementary techniques are required to confirm its presence in …

Mass spectrometric detection of ricin and its activity in food and clinical samples

SR Kalb, JR Barr - Analytical chemistry, 2009 - ACS Publications
Ricin is a potent toxin capable of inhibiting protein synthesis and causing death or
respiratory failure. Because of its high availability and lethality, ricin is considered a likely …

Detection and quantification of ricin in beverages using isotope dilution tandem mass spectrometry

SC McGrath, DM Schieltz, LG McWilliams… - Analytical …, 2011 - ACS Publications
The toxic plant protein ricin has gained notoriety due to wide availability and potential use as
a bioterrorism agent, with particular concern for food supply contamination. We have …

Identification and quantification of ricin in biomedical samples by magnetic immunocapture enrichment and liquid chromatography electrospray ionization tandem …

X Ma, J Tang, C Li, Q Liu, J Chen, H Li, L Guo… - Analytical and …, 2014 - Springer
Ricin is a toxic protein derived from castor beans and composed of a cytotoxic A chain and a
galactose-binding B chain linked by a disulfide bond, which can inhibit protein synthesis and …

[HTML][HTML] Methods to characterize ricin for the development of reference materials

SK Kim, DK Hancock, L Wang, KD Cole… - Journal of Research of …, 2006 - ncbi.nlm.nih.gov
Ricin is an abundant protein from the castor bean plant Ricinus communis. Because of its
high toxicity and the simplicity of producing mass quantities, ricin is considered a biological …

Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR

X He, S McMahon, TD Henderson, SM Griffey… - PloS one, 2010 - journals.plos.org
Background Ricin (also called RCA-II or RCA60), one of the most potent toxins and
documented bioweapons, is derived from castor beans of Ricinus communis. Several in vitro …